John Perrino

TL;DR: Cryo–electron microscopy can preserve reactive metals and thus reveal the atomic structure of a lithium metal dendrite and atomically resolve individual lithium metal atoms and their interface with the solid electrolyte interphase (SEI).

TL;DR: Although barrier function is impaired as early as 6 hr after stroke, TJs display profound structural defects only after 2 days, therefore, stepwise impairment of transcellular followed by paracellular barrier mechanisms accounts for the BBB deficits in stroke.

TL;DR: This study reveals a key role for glia in the removal of axon fragments during developmental axon pruning, using a genetically encoded electron microscopic (EM) marker to selectively label gamma neurons in the Drosophila mushroom bodies.

TL;DR: This work identifies large PML-NBs that sequester newly assembled nucleocapsids (NC) in neurons and satellite cells of human dorsal root ganglia (DRG) and skin cells infected with VZV in vivo and finds that PML IV cages co-sequester HttQ72 and ORF23 protein in VzV infected cells.

TL;DR: It is shown that the replication compartments of enteroviruses are created through novel membrane contact sites that recruit host lipid droplets to the RCs, and that pharmacological targeting of contact sites linking viral and host compartments is a potential strategy for antiviral development.