John Riches

TL;DR: Adult patients with hematologic malignancy and COVID-19, especially hospitalized patients, have a high risk of dying and adults aged ≥60 years have significantly higher mortality; pediatric patients appear to be relatively spared.

TL;DR: Although CLL CD8+ T cells exhibit features of T-cell exhaustion, they retain the ability to produce cytokines, and these findings also exclude CMV as the sole cause ofT-cell defects in CLL.

TL;DR: Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.

TL;DR: In this article, the authors provide a comprehensive roadmap of human B cell maturation with single-cell transcriptomics matched with bulk and singlecell antibody repertoires to define gene expression, antibody repertoire, and clonal sharing of B cell states at singlecell resolution, including memory B cell heterogeneity that reflects diverse functional and signaling states.

TL;DR: Direct comparisons of PD-1 expression and function between aging CLL mice and controls identifiedPD-1(+) T cells in CLL as a heterogeneous population with variable effector function, highly relevant for therapeutic targeting of CD8(+) T cells, showing the potential of reprogramming and selective subset expansion to restore antitumor immunity.