T
Tal Shay
Researcher at Ben-Gurion University of the Negev
Publications - 54
Citations - 8082
Tal Shay is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Regulation of gene expression & Gene. The author has an hindex of 30, co-authored 51 publications receiving 7073 citations. Previous affiliations of Tal Shay include Harvard University & Weizmann Institute of Science.
Papers
More filters
Journal ArticleDOI
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
Journal ArticleDOI
Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis
Noa Novershtern,Noa Novershtern,Noa Novershtern,Aravind Subramanian,Lee N. Lawton,Raymond H. Mak,W. Nicholas Haining,Marie McConkey,Naomi Habib,Nir Yosef,Cindy Y. Chang,Cindy Y. Chang,Tal Shay,Garrett M. Frampton,Adam Drake,Ilya B. Leskov,Björn Nilsson,Björn Nilsson,Fred Preffer,David Dombkowski,John W. Evans,Ted Liefeld,John S. Smutko,Jianzhu Chen,Nir Friedman,Richard A. Young,Todd R. Golub,Todd R. Golub,Todd R. Golub,Aviv Regev,Aviv Regev,Aviv Regev,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +34 more
TL;DR: In this paper, the authors profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression and analysis of cis-elements in gene promoters to decipher the general organization of their regulatory circuitry.
Journal ArticleDOI
Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma
Anastasia Murat,Eugenia Migliavacca,Thierry Gorlia,Wanyu L. Lambiv,Tal Shay,Marie-France Hamou,Nicolas de Tribolet,Luca Regli,Wolfgang Wick,Mathilde C.M. Kouwenhoven,Johannes A. Hainfellner,Frank L. Heppner,Pierre-Yves Dietrich,Yitzhak Zimmer,J. Gregory Cairncross,Robert-Charles Janzer,Eytan Domany,Mauro Delorenzi,Roger Stupp,Monika E. Hegi +19 more
TL;DR: This study provides first clinical evidence for the implication of a "glioma stem cell" or "self-renewal" phenotype in treatment resistance of glioblastoma.
Journal ArticleDOI
Deciphering the transcriptional network of the dendritic cell lineage
Jennifer Miller,Brian D. Brown,Tal Shay,Emmanuel L. Gautier,Emmanuel L. Gautier,Vladimir Jojic,Vladimir Jojic,Ariella Cohain,Gaurav Pandey,Marylene Leboeuf,Kutlu G. Elpek,Julie Helft,Daigo Hashimoto,Andrew Chow,Andrew Chow,Jeremy Price,Melanie Greter,Melanie Greter,Milena Bogunovic,Angelique Bellemare-Pelletier,Paul S. Frenette,Gwendalyn J. Randolph,Gwendalyn J. Randolph,Shannon J. Turley,Miriam Merad +24 more
TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.
Journal ArticleDOI
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses.
Ido Amit,Manuel Garber,Nicolas Chevrier,Ana Paula Leite,Ana Paula Leite,Yoni Donner,Thomas Eisenhaure,Mitchell Guttman,Mitchell Guttman,Jennifer K. Grenier,Weibo Li,Or Zuk,Lisa A. Schubert,Brian Birditt,Tal Shay,Alon Goren,Alon Goren,Xiaolan Zhang,Zachary D. Smith,Raquel P. Deering,Rebecca C. McDonald,Moran N. Cabili,Bradley E. Bernstein,Bradley E. Bernstein,John L. Rinn,Alexander Meissner,David E. Root,Nir Hacohen,Nir Hacohen,Aviv Regev,Aviv Regev,Aviv Regev +31 more
TL;DR: This study establishes a broadly applicable, comprehensive, and unbiased approach to reveal the wiring and functions of a regulatory network controlling a major transcriptional response in primary mammalian cells.