J
John S. Tzartos
Researcher at University of Oxford
Publications - 30
Citations - 1625
John S. Tzartos is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 7 publications receiving 1432 citations. Previous affiliations of John S. Tzartos include John Radcliffe Hospital.
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Journal ArticleDOI
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
John S. Tzartos,Manuel A. Friese,Matthew Craner,Jackie Palace,Jia Newcombe,Margaret M. Esiri,Lars Fugger,Lars Fugger +7 more
TL;DR: Observations suggest an enrichment of both IL-17+CD4+ and CD8+ T cells in active MS lesions as well as an important role for IL- 17 in MS pathogenesis, with some remarkable differences from the experimental autoimmune encephalomyelitis model.
Journal ArticleDOI
T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides
Maria Harkiolaki,Samantha L. Holmes,Samantha L. Holmes,Pia Svendsen,Jon W. Gregersen,Lise T. Jensen,Róisín M. McMahon,Róisín M. McMahon,Manuel A. Friese,Gijs I. van Boxel,Ruth Etzensperger,John S. Tzartos,Kamil R. Kranc,Sarah Sainsbury,Karl Harlos,Elizabeth D. Mellins,Jackie Palace,Margaret M. Esiri,P. Anton van der Merwe,E. Yvonne Jones,Lars Fugger,Lars Fugger +21 more
TL;DR: In this article, the authors show that a microbial peptide, common to several major classes of bacteria, can induce MS-like disease in humanized mice by crossreacting with a T cell receptor (TCR) that also recognizes a peptide from myelin basic protein, a candidate MS autoantigen.
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A preliminary neuropathological study of Japanese encephalitis in humans and a mouse model.
Allison German,Khin Saw Aye Myint,Nguyen Thi Hoang Mai,I M Pomeroy,Nguyen Hoan Phu,John S. Tzartos,Peter M Winter,Jennifer Collett,Jeremy Farrar,Alan D.T. Barrett,Anja Kipar,Margaret M. Esiri,Tom Solomon +12 more
TL;DR: There was new evidence suggestive of viral replication in the vascular endothelium, with endothelial cell damage, and beta-amyloid precursor protein staining indicated impaired axonal transport, which merits further investigation.
Journal ArticleDOI
IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain
John S. Tzartos,Matthew Craner,Manuel A. Friese,Karen B. Jakobsen,Jia Newcombe,Margaret M. Esiri,Lars Fugger +6 more
TL;DR: Findings suggest role(s) for IL-21 in both the acute and chronic stages of MS via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons.
Journal ArticleDOI
Axonal and oligodendrocyte-localized IgM and IgG deposits in MS lesions.
M. C. Sádaba,John S. Tzartos,Carlos L. Paíno,Mercedes García-Villanueva,José C. Álvarez-Cermeño,Luisa M. Villar,Margaret M. Esiri +6 more
TL;DR: These observations provide further evidence on the role of antibodies, complement and macrophages in plaque development, and strongly suggest they can induce axonal injury, an important cause of disability in MS.