L
Luisa M. Villar
Researcher at Hospital Universitario de Canarias
Publications - 171
Citations - 5108
Luisa M. Villar is an academic researcher from Hospital Universitario de Canarias. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 35, co-authored 152 publications receiving 4039 citations. Previous affiliations of Luisa M. Villar include University Hospital of Basel & University of Málaga.
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Journal ArticleDOI
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis
Claire Bridel,van Wieringen Wn,Henrik Zetterberg,Betty M. Tijms,Charlotte E. Teunissen,José C. Álvarez-Cermeño,Ulf Andreasson,Markus Axelsson,David Bäckström,Ales Bartos,Maria Bjerke,Kaj Blennow,Kaj Blennow,A. Boxer,Lena Brundin,Joachim Burman,Tove Christensen,Lenka Fialová,Lars Forsgren,Jette L. Frederiksen,Magnus Gisslén,Elizabeth Gray,Martin Gunnarsson,Sara Hall,Oskar Hansson,Megan K. Herbert,Joel Jakobsson,Jessen-Krut J,Shorena Janelidze,Gudmundur Johannsson,Gudmundur Johannsson,Michael Jonsson,Ludwig Kappos,Mohsen Khademi,Mohsen Khademi,Michael Khalil,Jens Kuhle,Mikael Landén,Leinonen,Giancarlo Logroscino,Lu Ch,Jan Lycke,Nadia K. Magdalinou,Andrea Malaspina,Niklas Mattsson,Lieke H.H. Meeter,Mehta,Signe Modvig,Tomas Olsson,Tomas Olsson,Ross W. Paterson,Pérez-Santiago J,Fredrik Piehl,Fredrik Piehl,Pijnenburg Yal,Pyykkö Ot,Ragnarsson O,Julio C. Rojas,Romme Christensen J,Sandberg L,Carole Scherling,Jonathan M. Schott,Finn Sellebjerg,Isabella Laura Simone,Tobias Skillbäck,Stilund M,Peter Sundström,Anders Svenningsson,Rosanna Tortelli,Carla Tortorella,Alessandro Trentini,Troiano M,Martin R Turner,van Swieten Jc,Mattias Vågberg,Marcel M. Verbeek,Luisa M. Villar,Pieter Jelle Visser,Pieter Jelle Visser,Anders Wallin,Weiss A,Carsten Wikkelsö,Edward J. Wild +82 more
TL;DR: The cNfL increased with age in HC and a majority of neurological conditions, although the association was strongest in HC, and has potential to assist the differentiation of FTD from AD and PD from atypical parkinsonian syndromes.
Journal ArticleDOI
Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis
Manuel Comabella,M. Fernández,Roland Martin,Stephanie Rivera-Vallvé,Eva Borràs,Cristina Chiva,Eva Julià,Alex Rovira,Ester Cantó,José C. Álvarez-Cermeño,Luisa M. Villar,Mar Tintoré,Xavier Montalban +12 more
TL;DR: Although protein levels are also increased in other disorders characterized by chronic inflammation, chitinase 3-like 1 may serve as a prognostic biomarker for conversion to multiple sclerosis and development of disability which may help to improve the understanding of the aetiopathogenesis in the early stages of multiple sclerosis.
Journal ArticleDOI
Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study
Jens Kuhle,Giulio Disanto,Ruth Dobson,Rocco Adiutori,Lucia Bianchi,Joanne Topping,Jonathan P. Bestwick,Ute-Christiane Meier,Monica Marta,G. Dalla Costa,Tessel F. Runia,E. P. Evdoshenko,N. Lazareva,Eric Thouvenot,Pietro Iaffaldano,Vita Direnzo,Mohsen Khademi,Fredrik Piehl,Manuel Comabella,Madeleine H. Sombekke,Joep Killestein,Harald Hegen,Scott L. Rauch,Sandra D'Alfonso,José C. Álvarez-Cermeño,P. Kleinova,Dana Horakova,Romy Roesler,Florian Lauda,Sara Llufriu,Timucin Avsar,Ugur Uygunoglu,Ayse Altintas,S. Saip,Til Menge,Cecilia Rajda,Roberto Bergamaschi,N. Moll,Michael Khalil,Romain Marignier,Irena Dujmovic,Henrik Larsson,Clas Malmeström,Elio Scarpini,Chiara Fenoglio,Stig Wergeland,Alice Laroni,Viviana Annibali,Silvia Romano,A.D. Martinez,Adriana Carrá,Marco Salvetti,Antonio Uccelli,Øivind Torkildsen,Kjell-Morten Myhr,Daniela Galimberti,Konrad Rejdak,Jan Lycke,Jette L. Frederiksen,Jelena Drulovic,Christian Confavreux,David Brassat,Christian Enzinger,Siegrid Fuchs,Isabel Bosca,Jean Pelletier,C. Picard,E. Colombo,Diego Franciotta,Tobias Derfuss,Raija L.P. Lindberg,Özgür Yaldizli,László Vécsei,B. C. Kieseier,H.-P. Hartung,Pablo Villoslada,Aksel Siva,Albert Saiz,Hayrettin Tumani,Eva Havrdova,Luisa M. Villar,Maurizio Leone,N. Barizzone,Florian Deisenhammer,Charlotte E. Teunissen,Xavier Montalban,Mar Tintoré,Tomas Olsson,Maria Trojano,Sylvain Lehmann,Giovanni Castelnovo,Sergey V. Lapin,Rogier Q. Hintzen,Ludwig Kappos,Roberto Furlan,Vittorio Martinelli,G. Comi,Sreeram V. Ramagopalan,Gavin Giovannoni +98 more
TL;DR: MRI lesion load, OCB and age at CIS are validated as the strongest independent predictors of conversion to CDMS in this multicentre setting.
Journal ArticleDOI
Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
Luisa M. Villar,M. C. Sádaba,Ernesto Roldán,Jaime Masjuan,P. González-Porqué,Noelia Villarrubia,Mercedes Espiño,J.A. García-Trujillo,A. Bootello,José C. Álvarez-Cermeño +9 more
TL;DR: The presence of intrathecal anti-myelin lipid IgM antibodies is a very accurate predictor of aggressive evolution in MS and the relationship between specificity and disease evolution is explored.
Journal ArticleDOI
Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis
Luisa M. Villar,Jaime Masjuan,P. González-Porqué,Jose F. Plaza,M. C. Sádaba,Ernesto Roldán,A. Bootello,José C. Álvarez-Cermeño +7 more
TL;DR: The follow‐up of a group of relapsing‐remitting MS patients for a longer time to evaluate whether the ITMS implies a poor prognosis, and the presence of oligoclonal IgM bands in cerebrospinal fluid is an unfavorable prognostic marker in MS.