Aurora Scrivo

TL;DR: A change of strategy in the modulation of autophagy might hold promise for future disease-modifying therapies for patients with neurodegenerative disorders.

TL;DR: In this article, the role of chaperone-mediated autophagy (CMA) in neuronal proteostasis was investigated using mouse models with systemic and neuronal-specific CMA blockage, showing that loss of neuronal CMA leads to altered neuronal function, selective changes in the neuronal metastable proteome, and proteotoxicity, all reminiscent of brain aging.

TL;DR: The term autophagy encompasses different pathways that route cytoplasmic material to lysosomes for degradation and includes macroautophagy, chaperone-mediated autophathy, and microautophathy as discussed by the authors .

TL;DR: A transgenic reporter mouse is developed that allows dynamic measurement of CMA activity in vivo using image-based procedures, and previously unknown spatial and temporal differences in CMAActivity in multiple organs and in response to stress are identified.

TL;DR: In this article, a loss-of-function mutation in the TSC1 gene was linked to tau accumulative disorders, including age-associated neurodegenerative disorders demonstrating tau-laden intracellular inclusions.