Johnna Devoto

TL;DR: The data indicate that the APOE ε4 allele is an important predictor of cognitive function in PD across multiple domains, and among PD patients without dementia, the APoe ε2/ε3/ε4 allele was only associated with lower performance on word list learning and semantic verbal fluency, a pattern more typical of the cognitive deficits seen in early Alzheimer disease than PD.

TL;DR: Loss‐of‐function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.

TL;DR: It is postulate that previously reported NPH cases with “dual” pathology more likely represent ventriculomegalic presentations of selected neurodegenerative disorders in which benefits from shunting may be short‐lived, with a consequently unfavorable risk‐benefit ratio.

TL;DR: Specific cognitive domains were differentially related to distinct PigD components, suggesting the presence of multiple neural pathways contributing to associations between cognition and PIGD symptoms in persons with PD.

TL;DR: Baseline cohort characteristics demonstrate a high rate of cognitive impairment in the sample, as well as potential sex differences with regard to cognitive diagnosis, and the PANUC Clinical Consortium is a clinically and cognitively well-characterized cohort of patients with PD.