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Ignacio F. Mata
Researcher at University of Washington
Publications - 69
Citations - 5228
Ignacio F. Mata is an academic researcher from University of Washington. The author has contributed to research in topics: Parkinson's disease & LRRK2. The author has an hindex of 24, co-authored 59 publications receiving 4405 citations. Previous affiliations of Ignacio F. Mata include Cleveland Clinic Lerner Research Institute & Cleveland Clinic.
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Journal ArticleDOI
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
Ellen Sidransky,Mike A. Nalls,Jan O. Aasly,Judith Aharon-Peretz,Grazia Annesi,Egberto Reis Barbosa,Anat Bar-Shira,Daniela Berg,Jose Bras,Jose Bras,Alexis Brice,Alexis Brice,Chiung-Mei Chen,Lorraine N. Clark,Christel Condroyer,Elvira Valeria De Marco,Alexandra Durr,Alexandra Durr,Michael J. Eblan,Stanley Fahn,Matthew J. Farrer,Hon-Chung Fung,Ziv Gan-Or,Thomas Gasser,Ruth Gershoni-Baruch,Ruth Gershoni-Baruch,Nir Giladi,Nir Giladi,Alida Griffith,Tanya Gurevich,Tanya Gurevich,Cristina Januário,Peter Kropp,Anthony E. Lang,Guey Jen Lee-Chen,Suzanne Lesage,Karen Marder,Ignacio F. Mata,Anat Mirelman,Jun Mitsui,Ikuko Mizuta,Giuseppe Nicoletti,Giuseppe Nicoletti,Catarina R. Oliveira,Ruth Ottman,Avi Orr-Urtreger,Lygia da Veiga Pereira,Aldo Quattrone,Aldo Quattrone,Ekaterina Rogaeva,Arndt Rolfs,Hanna Rosenbaum,Roberto Rozenberg,Ali Samii,Ali Samii,Ali Samii,Ted Samaddar,Claudia Schulte,Manu Sharma,Manu Sharma,Andrew B. Singleton,Andrew B. Singleton,Mariana Spitz,Mariana Spitz,Eng-King Tan,Eng-King Tan,Nahid Tayebi,Tatsushi Toda,André R. Troiano,Shoji Tsuji,Matthias Wittstock,Tyra G. Wolfsberg,Yih-Ru Wu,Cyrus P. Zabetian,Yi Zhao,Shira G. Ziegler +75 more
TL;DR: Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations.
Journal ArticleDOI
Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European Populations
Jennifer M. Kachergus,Ignacio F. Mata,Mary M. Hulihan,Julie P. Taylor,Sarah Lincoln,Jan O. Aasly,J. Mark Gibson,Owen A. Ross,Timothy Lynch,Timothy Lynch,Joseph Wiley,Joseph Wiley,Haydeh Payami,John G. Nutt,Demetrius M. Maraganore,Krzysztof Czyzewski,Maria Styczyńska,Zbigniew K. Wszolek,Matthew J. Farrer,Mathias Toft +19 more
TL;DR: It is demonstrated that LRRK2 G2019S accounts for parkinsonism in several families within Europe and North America, highlighting the fact that a proportion of clinically typical, late-onset PD cases have a genetic basis.
Journal ArticleDOI
APOE ε4 increases risk for dementia in pure synucleinopathies.
Debby W. Tsuang,James B. Leverenz,Oscar L. Lopez,Ronald L. Hamilton,David A. Bennett,Julie A. Schneider,Aron S. Buchman,Eric B. Larson,Eric B. Larson,Paul K. Crane,Jeffrey Kaye,Patricia L. Kramer,Randy Woltjer,John Q. Trojanowski,Daniel Weintraub,Daniel Weintraub,Alice Chen-Plotkin,David J. Irwin,Jacqueline Rick,Gerard D. Schellenberg,G. Stennis Watson,Walter A. Kukull,Peter T. Nelson,Gregory A. Jicha,Janna H. Neltner,Doug R. Galasko,Eliezer Masliah,Joseph F. Quinn,Kathryn A. Chung,Dora Yearout,Ignacio F. Mata,Jia Y. Wan,Karen L. Edwards,Thomas J. Montine,Cyrus P. Zabetian +34 more
TL;DR: The elevated ϵ4 frequency in the pDLB and PDD groups, in which the overall brain neuritic plaque burden was low, indicates that apoE might contribute to neurodegeneration through mechanisms unrelated to amyloid processing.
Journal ArticleDOI
The Genetics of Parkinson Disease
TL;DR: The prevalence, incidence, clinical manifestations, and genetic components of PD are discussed in this review.
Journal ArticleDOI
Glucocerebrosidase Gene Mutations: A Risk Factor for Lewy Body Disorders
Ignacio F. Mata,Ali Samii,Seth H. Schneer,John W. Roberts,Alida Griffith,Berta C. Leis,Gerard D. Schellenberg,Ellen Sidransky,Thomas D. Bird,James B. Leverenz,Debby W. Tsuang,Cyrus P. Zabetian +11 more
TL;DR: The findings suggest that GBA mutations exert a large effect on susceptibility for Lewy body disorders at the individual level but are associated with a modest population-attributable risk in individuals of European ancestry.