Showing papers by "Jon Clardy published in 1981"
697 citations
471 citations
206 citations
TL;DR: A new antileukemic taxane alkaloid, cephalomannine (Ia), has been isolated from leaves, stems, and roots of Taxus wallichiana Zucco.
Abstract: A new antileukemic taxane alkaloid, cephalomannine (Ia), has been isolated from leaves, stems, and roots of Taxus wallichiana Zucco Cephalomannine is closely related to taxol (Ib), a previously characterized antileukemic alkaloid, which also occurs in T. wallichiana but in lesser amounts than cephalomannine. The new alkaloid and its hydrolysis products were characterized by nuclear magnetic resonance, mass spectroscopy, and X-ray crystallography; taxol and two cytotoxic taxane congeners were also identified.
192 citations
61 citations
TL;DR: In this article, two sesquiterpenoids of the unprecedented neoiemnane ring system and one eremophflane-derived diol have been isolated from the pacific soft-coral Lemnalia africana.
37 citations
36 citations
TL;DR: In this article, organometallics to chiral 3-pyridyl oxazolines gave high diastereoselectivity at the 4 position of the pyridine nucleus.
34 citations
TL;DR: In this paper, four new oxygenated tricyclic diterpenoids have been isolated from the Caribean brown alga Dictyota dicaricato.
33 citations
TL;DR: In this article, an X-ray crystallographic structure determination of sterpuric acid (1) was presented, as well as the structures and reactions of methyl hydroxysterpurate (1), methyl hyperedylidene acetal (22 ) and methyl hydroxysterpurate(1) for the Stereum purpureum disease.
30 citations
TL;DR: Flow pyrolysis of allylcyclopentadienyldimethylsilane and 1-dimethylmethoxysilyl-1-trimethylsilylcyclopentadiene afforded 6, 6dimethyl-6-silafulvene which was either trapped or allowed to dimerize as mentioned in this paper.
TL;DR: The structure of luteone, a twenty three carbon terpenoid, has been solved by performing a single crystal x-ray analysis on a 3,4-dinitrophenylhydrazone derivative as discussed by the authors.
TL;DR: In this paper, a Mannich-directed 2-azonia-[3,3]-sigmatropic rearrangement was used for the preparation of 9a-aryl hydrolilolidines.
TL;DR: The steroechemistry of guggulsterol-1, a component of the exudate of Commiphora mukul, is shown to be 20(R), 22(R)( 3 ).
TL;DR: The structure of acumycin, an antibiotic isolated from Streptomyces griseoflavus, was determined from spectroscopic and X-ray studies.
TL;DR: In this paper, an efficient synthesisation of vafzelin and syncarpin, unusual plant metabolites from Uvaria afzelii, is described. But the synthesis is restricted to a single plant.