Tomoaki Ida

TL;DR: It is proposed that reactive Cys persulfides and S-polythiolation have critical regulatory functions in redox cell signaling and H2S may act primarily as a marker for the biologically active of persulfide species.

TL;DR: Targeted disruption of the genes encoding mitochondrial CARSs in mice and human cells shows that CARS have a crucial role in endogenous CysSSH production and suggests that these enzymes serve as the principal cysteine persulfide synthases in vivo.

TL;DR: The recent finding of Cys‐SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH.

TL;DR: This study precisely quantified NO-dependent formation of 8-nitro-cGMP in C6 glioma cells via liquid chromatography-tandem mass spectrometry and confirmed the first substantial corroboration of the biological significance of cellular 8- Nitroguanosine 3′,5′-cyclic monophosphate, rather than cGMP per se, in the Nrf2-dependent antioxidant response.

TL;DR: CysSSH protects Cys from irreversible oxidative loss of function by the formation of CysSSO1-3H derivatives that can subsequently be reduced back to native thiols, suggesting a role for TrxR1/TRP14-regulated oxidative persulfidation in growth factor responsiveness.