J
Jonathan A. Fletcher
Researcher at Brigham and Women's Hospital
Publications - 426
Citations - 57627
Jonathan A. Fletcher is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: GiST & PDGFRA. The author has an hindex of 109, co-authored 413 publications receiving 53642 citations. Previous affiliations of Jonathan A. Fletcher include Albany Medical College & Oregon Health & Science University.
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Journal ArticleDOI
Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors
César Serrano,Ana Vivancos,Antonio Lopez-Pousa,Judith Matito,Francesco M. Mancuso,Claudia Valverde,Sergi Quiroga,Stefania Landolfi,Sandra Castro,Cristina Dopazo,Ana Sebio,Anna C. Virgili,María M. Menso,Javier Martin-Broto,Miriam Sansó,Alfonso García-Valverde,Jordi Rosell,Jonathan A. Fletcher,Suzanne George,Joan Carles,Joaquín Arribas +20 more
TL;DR: CTDNA evaluation with amplicon-based NGS detects KIT primary and secondary mutations in metastatic GIST patients, particularly after imatinib progression, finding that GIST had relatively low ctDNA shedding, and mutations were at low allele frequencies.
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Detection of chromosome 18 rearrangement in synovial sarcoma by fluorescence in situ hybridization.
TL;DR: The FISH analyses were consistent with chromosome 18 translocation in 6 of 7 synovial sarcomas, 0 of 3 hemangiopericytomas, and 0 of 1 mesothelioma, and support the use of FISH in the diagnosis of synovia sarcoma.
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Percutaneous biopsy of peripheral primitive neuroectodermal tumors and Ewing's sarcomas for cytogenetic analysis.
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Clinical relevance of pharmacogenetics in gastrointestinal stromal tumor treatment in the era of personalized therapy.
Sabrina Angelini,Gloria Ravegnini,Gloria Ravegnini,Jonathan A. Fletcher,Francesca Maffei,Patrizia Hrelia +5 more
TL;DR: The authors review how tumor genotypes, in particular KIT and PDGFRA mutational analysis, have been integrated in the optimal clinical management of GIST patients and discuss the potential practical relevance of pharmacogenetics.
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Isochromosome 7q in adult Wilms' tumors: Diagnostic and pathogenetic implications
Brian P. Rubin,Michael R. Pins,G. Petur Nielsen,Seymour Rosen,Bae Li Hsi,Jonathan A. Fletcher,Andrew A. Renshaw +6 more
TL;DR: The characteristic findings of isochromosome 7q, lack of trisomy or tetrasomy for chromosome 12, and absence of persistent renal blastema suggest that the pathogenesis of Wilms' tumors in adults may be different than in the pediatric population.