J
Jonathan A. Fletcher
Researcher at Brigham and Women's Hospital
Publications - 426
Citations - 57627
Jonathan A. Fletcher is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: GiST & PDGFRA. The author has an hindex of 109, co-authored 413 publications receiving 53642 citations. Previous affiliations of Jonathan A. Fletcher include Albany Medical College & Oregon Health & Science University.
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Journal ArticleDOI
Prognostic implications of cytogenetic studies in an intensively treated group of children with acute lymphoblastic leukemia.
Jonathan A. Fletcher,Virginia M. Kimball,Elizabeth A. Lynch,Mia Donnelly,Karen Pavelka,Richard D. Gelber,Ramana Tantravahi,Stephen E. Sallan +7 more
TL;DR: The absence of karyotypic prognostic significance was observed not only within the overall group, but also when the results were stratified by standard-risk and high-risk status and of the specific structural chromosome changes that the authors studied, only the Philadelphia chromosome appeared to confer a poor prognosis.
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Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma
Chueh Chuan Yen,Chueh Chuan Yen,Wei Ming Chen,Tain Hsiung Chen,Winby Chen,Paul Chih-Hsueh Chen,Hong Jen Chiou,Giun Yi Hung,Hung Ta Hondar Wu,Chao Jung Wei,Cheng Ying Shiau,Yu Chung Wu,Ta Chung Chao,Cheng Hwai Tzeng,Po Min Chen,Chi Hung Lin,Yann Jang Chen,Yann Jang Chen,Jonathan A. Fletcher +18 more
TL;DR: This SNP genotyping study identified chromosomal aberrations associated with disease progression in OS and disclosed LSAMP as a novel tumor suppressor gene in OS.
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Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRα, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants
Ellen Weisberg,Hwan Geun Choi,Arghya Ray,Rosemary Barrett,Jianming Zhang,Taebo Sim,Wenjun Zhou,Markus A. Seeliger,Michael D. Cameron,Mohammed Azam,Jonathan A. Fletcher,Maria Debiec-Rychter,Mark Mayeda,Daisy Moreno,Andrew L. Kung,Pasi A. Jänne,Roya Khosravi-Far,Junia V. Melo,Paul W. Manley,Sophia Adamia,Catherine J. Wu,Nathanael S. Gray,James D. Griffin +22 more
TL;DR: HG-7-85-01 is unique among all currently reported kinase inhibitors in having the ability to accommodate either a gatekeeper threonine, present in the wild-type forms of these kinases, or a large hydrophobic amino acid without becoming a promiscuous kinase inhibitor.
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Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma.
Robert Nakayama,Yi Xiang Zhang,Jeffrey T. Czaplinski,Alex J. Anatone,Ewa Sicinska,Jonathan A. Fletcher,George D. Demetri,Andrew J. Wagner +7 more
TL;DR: The results indicate that selinexor has potent in vitro and in vivo activity against a wide variety of sarcoma models by inducing G1-arrest independent of known molecular mechanisms in GIST and LPS.
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Mechanism of association between BMI and dysfunction of the gastro-oesophageal barrier in patients with normal endoscopy
Mohammad H. Derakhshan,Elaine V. Robertson,Jonathan A. Fletcher,Gareth-Rhys Jones,Yeong Yeh Lee,Angela A. Wirz,Kenneth E.L. McColl +6 more
TL;DR: The association between reflux and BMI may be largely explained by effects of increased intra-abdominal pressure, however, the reduced LOS pressure associated with BMI might be mediated by another mechanism or effects of chronic rather than acute elevation of intra-ABdominal Pressure.