J
Jonathan A. Fletcher
Researcher at Brigham and Women's Hospital
Publications - 426
Citations - 57627
Jonathan A. Fletcher is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: GiST & PDGFRA. The author has an hindex of 109, co-authored 413 publications receiving 53642 citations. Previous affiliations of Jonathan A. Fletcher include Albany Medical College & Oregon Health & Science University.
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Journal ArticleDOI
Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors.
Yuan Shuo Hsueh,Yuan Shuo Hsueh,Hui Hua Chang,Yan Shen Shan,H. Sunny Sun,Jonathan A. Fletcher,Chien-Feng Li,Chien-Feng Li,Li-Tzong Chen +8 more
TL;DR: The results demonstrate the existence of a nuclear KIT-driven NFKBIB-RELA-KIT autoregulatory loop in GIST tumorigenesis, which are potential targets for developing combination therapy to overcome imatinib-resistant of K IT-expressing GISTs.
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Molecular Detection of PPARγ Rearrangements and Thyroid Carcinoma in Preoperative Fine-Needle Aspiration Biopsies
Christopher A. French,Jonathan A. Fletcher,Edmund S. Cibas,Christopher Caulfield,Paulette Allard,Todd G. Kroll +5 more
TL;DR: It is demonstrated that PPARγ rearrangements can detect a subset of follicular-patterned thyroid carcinomas in preoperative thyroid fine-needle aspiration biopsies.
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Distinctive IGH gene segment usage and minimal residual disease detection in infant acute lymphoblastic leukaemias.
Aihong Li,Meredith A. Goldwasser,Jianbiao Zhou,Scott A. Armstrong,Hongjun Wang,Virginia Dalton,Jonathan A. Fletcher,Stephen E. Sallan,Lewis B. Silverman,John G. Gribben +9 more
TL;DR: Low levels of minimal residual disease at the end of induction appeared to be high in infants with ALL compared with older children, and there were no differences in MRD levels after induction therapy in infant ALL with or without MLL gene rearrangements.
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Fluorescent in situ hybridization assessment of chromosome 7 copy number in uncultured lung and kidney cells
TL;DR: FISH was used to assess chromosome 7 copy number in uncultured interphase nuclei from lung and kidney specimens and indicated a potential wide margin of error in quantifying these events.
Journal ArticleDOI
Lineage-restricted chromosome translocation in a benign fibrous tumor of the breast
Frances Belda,Frances Belda,Susan C. Lester,Susan C. Lester,Jack L. Pinkus,Jack L. Pinkus,Geraldine S. Pinkus,Geraldine S. Pinkus,Jonathan A. Fletcher,Jonathan A. Fletcher +9 more
TL;DR: A combined immunohistochemical/cytogenetic study demonstrated that cells with the clonal translocation were mesenchymal and Epithelial cells, in contrast, had normal chromosomes.