J
Jonathan A. Fletcher
Researcher at Brigham and Women's Hospital
Publications - 426
Citations - 57627
Jonathan A. Fletcher is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: GiST & PDGFRA. The author has an hindex of 109, co-authored 413 publications receiving 53642 citations. Previous affiliations of Jonathan A. Fletcher include Albany Medical College & Oregon Health & Science University.
Papers
More filters
Journal ArticleDOI
PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.
Jing Chen,Daniel J. DeAngelo,Jeffery L. Kutok,Ifor R. Williams,Benjamin H. Lee,Martha Wadleigh,Nicole Duclos,Sarah L. Cohen,Jennifer Adelsperger,Rachel Okabe,Allison Coburn,Ilene Galinsky,Brian J. P. Huntly,Pamela S. Cohen,Thomas F. Meyer,Doriano Fabbro,Johannes Roesel,Lolita Banerji,James D. Griffin,Sheng Xiao,Jonathan A. Fletcher,Richard Stone,D. Gary Gilliland +22 more
TL;DR: A small-molecule tyrosine kinase inhibitor, PKC412 was administered to a patient with t(8;13)(p11;q12) and was efficacious in treatment of progressive myeloproliferative disorder with organomegaly and resulted in statistically significant prolongation of survival in the murine model of ZNF198-FGFR1-induced MPD.
Journal Article
Codeletion of p15 and p16 in primary malignant mesothelioma
TL;DR: Findings demonstrate that p15, p16 and/or a closely neighboring gene, are the targets of frequent chromosome 9p deletion in primary malignant mesothelioma.
Journal Article
Cytogenetic abnormalities in uterine leiomyomata.
Mitchell S. Rein,Andrew J. Friedman,Robert L. Barbieri,Karen Pavelka,Jonathan A. Fletcher,Cynthia C. Morton +5 more
TL;DR: It is suggested that spontaneous chromosome rearrangements may be responsible for the initiation and proliferation of leiomyoma growth.
Journal ArticleDOI
Familial Gastrointestinal Stromal Tumor Syndrome: Phenotypic and Molecular Features in a Kindred
Frederick P. Li,Jonathan A. Fletcher,Michael Heinrich,Judy Garber,Stephen E. Sallan,Clara Curiel-Lewandrowski,Anette Duensing,Matt van de Rijn,Lowell E. Schnipper,George D. Demetri +9 more
TL;DR: These studies provide the first evidence that gene expression and mechanisms of cytogenetic progression and cell signaling are indistinguishable in familial and sporadic GISTs.
Journal ArticleDOI
Pediatric KIT–Wild-Type and Platelet-Derived Growth Factor Receptor α–Wild-Type Gastrointestinal Stromal Tumors Share KIT Activation but not Mechanisms of Genetic Progression with Adult Gastrointestinal Stromal Tumors
Katherine A. Janeway,Bernadette Liegl,Amy Harlow,Claudia Le,Antonio R. Perez-Atayde,Harry P.W. Kozakewich,Christopher L. Corless,Michael Heinrich,Jonathan A. Fletcher +8 more
TL;DR: Most pediatric KIT-wild-type GISTs progress to malignancy without acquiring large-scale chromosomal aberrations, which is a phenomenon not reported previously in malignant solid tumors, suggesting that KIT may play an important role in oncogenesis.