J
Jonathan D. Ellis
Researcher at University of Toronto
Publications - 5
Citations - 2912
Jonathan D. Ellis is an academic researcher from University of Toronto. The author has contributed to research in topics: Alternative splicing & RNA splicing. The author has an hindex of 5, co-authored 5 publications receiving 2507 citations.
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Journal ArticleDOI
The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation.
Vidisha Tripathi,Jonathan D. Ellis,Zhen Shen,David Y. Song,Qun Pan,Andrew T. Watt,Susan M. Freier,C. Frank Bennett,Alok Sharma,Paula A. Bubulya,Benjamin J. Blencowe,Supriya G. Prasanth,Kannanganattu V. Prasanth +12 more
TL;DR: Evidence is provided for a role for the long nuclear-retained regulatory RNA, MALAT1 in AS regulation and for the role for an nrRNA in the regulation of gene expression, which suggests that MALat1 regulates AS by modulating the levels of active SR proteins.
Journal ArticleDOI
A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains
Manuel Irimia,Manuel Irimia,Robert J. Weatheritt,Jonathan D. Ellis,Neelroop N. Parikshak,Thomas Gonatopoulos-Pournatzis,Mariana Babor,Mathieu Quesnel-Vallières,Javier Tapial,Bushra Raj,Dave O'Hanlon,Miriam Barrios-Rodiles,Michael J.E. Sternberg,Sabine P. Cordes,Frederick P. Roth,Jeffrey L. Wrana,Jeffrey L. Wrana,Daniel H. Geschwind,Benjamin J. Blencowe +18 more
TL;DR: The results reveal a highly conserved program of dynamic microexon regulation associated with the remodeling of protein-interaction networks during neurogenesis, the misregulation of which is linked to autism.
Journal ArticleDOI
Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks
Jonathan D. Ellis,Miriam Barrios-Rodiles,Recep Colak,Manuel Irimia,TaeHyung Kim,John A. Calarco,Xinchen Wang,Qun Pan,Dave O'Hanlon,Philip M. Kim,Jeffrey L. Wrana,Jeffrey L. Wrana,Benjamin J. Blencowe +12 more
TL;DR: In this paper, the authors observed that brain and other tissue-regulated exons are significantly enriched in flexible regions of proteins that likely form conserved interaction surfaces, including Bridging Integrator 1 (Bin1)/Amphiphysin II and Dynamin 2 (Dnm2).
Journal ArticleDOI
Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons
Thomas Gonatopoulos-Pournatzis,Mingkun Wu,Ulrich Braunschweig,Jonathan Roth,Hong Han,Andrew J. Best,Bushra Raj,Michael Aregger,Dave O'Hanlon,Jonathan D. Ellis,John A. Calarco,Jason Moffat,Anne-Claude Gingras,Benjamin J. Blencowe +13 more
TL;DR: A CRISPR-based strategy for the genome-wide elucidation of pathways that control splicing and apply it to microexons with important functions in nervous system development and that are commonly misregulated in autism is described.
Book ChapterDOI
LUMIER: A Discovery Tool for Mammalian Protein Interaction Networks.
Miriam Barrios-Rodiles,Jonathan D. Ellis,Benjamin J. Blencowe,Jeffrey L. Wrana,Jeffrey L. Wrana +4 more
TL;DR: A manual version of LUMIER is described in a 96-well format that can be easily implemented in any laboratory and is a valuable tool for the identification and characterization of dynamically regulated PPIs in mammalian systems.