M
Manuel Irimia
Researcher at Pompeu Fabra University
Publications - 160
Citations - 11458
Manuel Irimia is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Alternative splicing & Gene. The author has an hindex of 45, co-authored 132 publications receiving 9274 citations. Previous affiliations of Manuel Irimia include Catalan Institution for Research and Advanced Studies & University of Toronto.
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Journal ArticleDOI
A compendium of RNA-binding motifs for decoding gene regulation
Debashish Ray,Hilal Kazan,Kate B. Cook,Matthew T. Weirauch,Matthew T. Weirauch,Hamed S. Najafabadi,Xiao Li,Serge Gueroussov,Mihai Albu,Hong Zheng,Ally Yang,Hong Na,Manuel Irimia,Leah H. Matzat,Ryan K. Dale,Sarah A. Smith,Christopher A. Yarosh,Seth M. Kelly,Behnam Nabet,D. Mecenas,Weimin Li,Rakesh S. Laishram,Mei Qiao,Howard D. Lipshitz,Fabio Piano,Anita H. Corbett,Russ P. Carstens,Brendan J. Frey,Richard A. Anderson,Kristen W. Lynch,Luiz O. F. Penalva,Elissa P. Lei,Andrew G. Fraser,Benjamin J. Blencowe,Quaid Morris,Timothy P. Hughes +35 more
TL;DR: A systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes from 24 diverse eukaryotes, provides an unprecedented overview of RNA- binding proteins and their targets, and constitute an invaluable resource for determining post-transcriptional regulatory mechanisms in eukARYotes.
Journal ArticleDOI
The Evolutionary Landscape of Alternative Splicing in Vertebrate Species
Nuno L. Barbosa-Morais,Nuno L. Barbosa-Morais,Manuel Irimia,Qun Pan,Hui Yuan Xiong,Serge Gueroussov,Leo J. Lee,Valentina Slobodeniuc,Claudia Kutter,Stephen Watt,Recep Colak,TaeHyung Kim,Christine M. Misquitta-Ali,Michael D. Wilson,Michael D. Wilson,Philip M. Kim,Duncan T. Odom,Duncan T. Odom,Brendan J. Frey,Benjamin J. Blencowe +19 more
TL;DR: The findings suggest that the evolution of alternative splicing has for the most part been very rapid and thatAlternative splicing patterns of most organs more strongly reflect the identity of the species rather than the organ type, with the highest complexity in primates.
Journal ArticleDOI
Elephant shark genome provides unique insights into gnathostome evolution
Byrappa Venkatesh,Byrappa Venkatesh,Alison P. Lee,Vydianathan Ravi,Ashish K. Maurya,Michelle M. Lian,Jeremy B. Swann,Yuko Ohta,Martin F. Flajnik,Yoichi Sutoh,Masanori Kasahara,Shawn Hoon,Vamshidhar Gangu,Scott William Roy,Manuel Irimia,Vladimir Korzh,Igor Kondrychyn,Zhi Wei Lim,Boon Hui Tay,Sumanty Tohari,Kiat Whye Kong,Shufen Ho,Belen Lorente-Galdos,Belen Lorente-Galdos,Javier Quilez,Javier Quilez,Tomas Marques-Bonet,Tomas Marques-Bonet,Brian J. Raney,Philip W. Ingham,Alice Tay,LaDeana W. Hillier,Patrick Minx,Thomas Boehm,Richard K. Wilson,Sydney Brenner,Wesley C. Warren +36 more
TL;DR: The whole-genome analysis of a cartilaginous fish, the elephant shark (Callorhinchus milii), finds that the C. milii genome is the slowest evolving of all known vertebrates, and features extensive synteny conservation with tetrapod genomes, making it a good model for comparative analyses of gnathostome genomes.
Journal ArticleDOI
Widespread intron retention in mammals functionally tunes transcriptomes
Ulrich Braunschweig,Nuno L. Barbosa-Morais,Nuno L. Barbosa-Morais,Qun Pan,Emil N. Nachman,Babak Alipanahi,Thomas Gonatopoulos-Pournatzis,Brendan J. Frey,Manuel Irimia,Benjamin J. Blencowe +9 more
TL;DR: It is shown that intron retention acts widely to reduce the levels of transcripts that are less or not required for the physiology of the cell or tissue type in which they are detected, and this "transcriptome tuning" function of IR acts through both nonsense-mediated mRNA decay and nuclear sequestration and turnover of IR transcripts.
Journal ArticleDOI
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
Neelroop N. Parikshak,Vivek Swarup,T. Grant Belgard,Manuel Irimia,Gokul Ramaswami,Michael J. Gandal,Christopher Hartl,Virpi Leppa,Luis de la Torre Ubieta,Jerry Huang,Jennifer K. Lowe,Benjamin J. Blencowe,Steve Horvath,Daniel H. Geschwind +13 more
TL;DR: Post-mortem genome-wide transcriptome analysis of the largest cohort of samples analysed so far, to the knowledge, interrogate the noncoding transcriptome, alternative splicing, and upstream molecular regulators to broaden the understanding of molecular convergence in ASD.