M
Matthew J. Tyska
Researcher at Vanderbilt University
Publications - 106
Citations - 5758
Matthew J. Tyska is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Myosin & Brush border. The author has an hindex of 35, co-authored 99 publications receiving 4722 citations. Previous affiliations of Matthew J. Tyska include Yale University & Vanderbilt University Medical Center.
Papers
More filters
Journal ArticleDOI
Exosome secretion is enhanced by invadopodia and drives invasive behavior.
Daisuke Hoshino,Kellye C. Kirkbride,Kaitlin Costello,Emily S. Clark,Seema Sinha,Nathan E. Grega-Larson,Matthew J. Tyska,Alissa M. Weaver +7 more
TL;DR: This work identified specialized invasive actin structures called invadopodia as specific and critical docking and secretion sites for CD63- and Rab27a-positive MVEs and revealed a fundamental role for exosomes in promoting cancer cell invasiveness.
Journal ArticleDOI
Amphiregulin Exosomes Increase Cancer Cell Invasion
James N. Higginbotham,Michelle Demory Beckler,Jonathan Gephart,Jeffrey L. Franklin,Galina Bogatcheva,Gert-Jan Kremers,David W. Piston,Gregory D. Ayers,Russell E. McConnell,Matthew J. Tyska,Robert J. Coffey,Robert J. Coffey +11 more
TL;DR: It is speculated that EGFR ligand signaling via exosomes might contribute to diverse cancer phenomena such as field effect and priming of the metastatic niche.
Journal ArticleDOI
The enterocyte microvillus is a vesicle-generating organelle.
Russell E. McConnell,James N. Higginbotham,David A. Shifrin,David L. Tabb,Robert J. Coffey,Matthew J. Tyska +5 more
TL;DR: Data is presented showing that enterocyte microvilli function as vesicle-generating organelles, which enable enterocytes to deploy catalytic activities into the intestinal lumen.
Journal ArticleDOI
Cortactin promotes exosome secretion by controlling branched actin dynamics.
Seema Sinha,Daisuke Hoshino,Nan Hyung Hong,Kellye C. Kirkbride,Nathan E. Grega-Larson,Motoharu Seiki,Matthew J. Tyska,Alissa M. Weaver,Alissa M. Weaver +8 more
TL;DR: It is shown that the cytoskeletal and tumor-overexpressed protein cortactin promotes secretion of exosomes from cancer cells by stabilizing dynamic cortical actin docking sites for multivesicular endosomes, suggesting a potential mechanism by which Cortactin may promote tumor aggressiveness.
Journal ArticleDOI
Single-Molecule Mechanics of R403Q Cardiac Myosin Isolated From the Mouse Model of Familial Hypertrophic Cardiomyopathy
Matthew J. Tyska,E. Hayes,Michael Giewat,Christine E. Seidman,Jonathan G. Seidman,David M. Warshaw +5 more
TL;DR: On the basis of the distribution of mean unitary displacements, this mutation may possibly perturb the mechanical coordination between the 2 heads of cardiac myosin and result in abnormal power output and potentially a stimulus for the hypertrophic response.