J
Jongyun Myeong
Researcher at New Generation University College
Publications - 23
Citations - 389
Jongyun Myeong is an academic researcher from New Generation University College. The author has contributed to research in topics: Transient receptor potential channel & TRPC. The author has an hindex of 10, co-authored 20 publications receiving 293 citations. Previous affiliations of Jongyun Myeong include University of Washington.
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Journal ArticleDOI
Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease
Chansik Hong,Hyemyung Seo,Misun Kwak,Jeha Jeon,Jihoon Jang,Eui Man Jeong,Jongyun Myeong,Yu Jin Hwang,Kotdaji Ha,Min Jueng Kang,Kyu Pil Lee,Eugene C. Yi,In Gyu Kim,Ju Hong Jeon,Hoon Ryu,Hoon Ryu,Insuk So +16 more
TL;DR: Increased TRPC5 S-glutathionylation by oxidative stress and decreased TRPC1 expression contribute to neuronal damage in the striatum and may underlie neurodegeneration in Huntington's disease.
Journal ArticleDOI
The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels
Hana Kim,Jinsung Kim,Jaepyo Jeon,Jongyun Myeong,Jinhong Wie,Chansik Hong,Hyun-Jin Kim,Ju Hong Jeon,Insuk So +8 more
TL;DR: Potential roles for Gαi/o proteins in channel activation in addition to their known role in cellular signaling are discussed.
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Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels
Jinsung Kim,Misun Kwak,Jaepyo Jeon,Jongyun Myeong,Jinhong Wie,Chansik Hong,Sung Young Kim,Ju Hong Jeon,Hyun-Jin Kim,Insuk So +9 more
TL;DR: It is demonstrated that TRPC1/4 channel shows dynamic gating property depending onTRPC1 isoform subtypes and receptor stimulation system, and careful discrimination of the specificity of TR PC1 isoforms and upstream activation system is important in thorough understanding of TRPC 1 and TRPC2/4 channels.
Journal ArticleDOI
Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains.
TL;DR: In this article, two differently lipidated peptide sequences, L10 and S15, were used as Forster resonance energy transfer (FRET) pairs in intact cells to mark liquid-ordered, cholesterol-rich (Lo) and liquid-disordered and cholesterol-poor (Ld) domains of the PM.
Journal ArticleDOI
Dual Action of the Gα q-PLCβ-PI(4,5)P 2 Pathway on TRPC1/4 and TRPC1/5 Heterotetramers
Jongyun Myeong,Juyeon Ko,Misun Kwak,Jinsung Kim,Joohan Woo,Kotdaji Ha,Chansik Hong,Dongki Yang,Hyun-Jin Kim,Ju Hong Jeon,Insuk So +10 more
TL;DR: Evidence is provided indicating that Gαq protein directly interacts with either TRPC4 or TRPC5 of the heterotetrameric channels to permit activation, which leads to the breakdown of PI(4,5)P2, which inhibits activity of TRPC1/4 and 1/5 channels.