Y
Yu Jin Hwang
Researcher at Korea Institute of Science and Technology
Publications - 26
Citations - 1516
Yu Jin Hwang is an academic researcher from Korea Institute of Science and Technology. The author has contributed to research in topics: Neurodegeneration & Huntington's disease. The author has an hindex of 19, co-authored 26 publications receiving 1110 citations. Previous affiliations of Yu Jin Hwang include New Generation University College & Seoul National University.
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Journal ArticleDOI
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
Seonmi Jo,Seonmi Jo,Oleg Yarishkin,Yu Jin Hwang,Ye Eun Chun,Mijeong Park,Dong Ho Woo,Jin Young Bae,Taekeun Kim,Jaekwang Lee,Heejung Chun,Hyun Jung Park,Da Yong Lee,Jinpyo Hong,Hye Yun Kim,Soo Jin Oh,Seung Ju Park,Hyo Seon Lee,Bo-Eun Yoon,Young-Soo Kim,Yong Jeong,Insop Shim,Yong Chul Bae,Jeiwon Cho,Neil W. Kowall,Neil W. Kowall,Hoon Ryu,Hoon Ryu,Hoon Ryu,Eunmi Hwang,Daesoo Kim,C. Justin Lee +31 more
TL;DR: It is proposed that selective inhibition of astrocytic GABA synthesis or release may serve as an effective therapeutic strategy for treating memory impairment in AD.
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SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease.
Junghee Lee,Junghee Lee,Y. S. Kim,Tian Liu,Yu Jin Hwang,Seung Jae Hyeon,Hyeonjoo Im,Kyung-Eun Lee,Victor E. Alvarez,Victor E. Alvarez,Ann C. McKee,Ann C. McKee,Soo-Jong Um,Man-Wook Hur,Inhee Mook-Jung,Neil W. Kowall,Neil W. Kowall,Hoon Ryu,Hoon Ryu,Hoon Ryu +19 more
TL;DR: Therapeutic modulation of SIRT3 activity may ameliorate mitochondrial pathology and neurodegeneration in AD and prevent p53‐induced mitochondrial dysfunction and neuronal damage in AD.
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Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease
Chansik Hong,Hyemyung Seo,Misun Kwak,Jeha Jeon,Jihoon Jang,Eui Man Jeong,Jongyun Myeong,Yu Jin Hwang,Kotdaji Ha,Min Jueng Kang,Kyu Pil Lee,Eugene C. Yi,In Gyu Kim,Ju Hong Jeon,Hoon Ryu,Hoon Ryu,Insuk So +16 more
TL;DR: Increased TRPC5 S-glutathionylation by oxidative stress and decreased TRPC1 expression contribute to neuronal damage in the striatum and may underlie neurodegeneration in Huntington's disease.
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Epigenetic Mechanisms of Neurodegeneration in Huntington’s Disease
Junghee Lee,Yu Jin Hwang,Ki Yoon Kim,Neil W. Kowall,Neil W. Kowall,Hoon Ryu,Hoon Ryu,Hoon Ryu +7 more
TL;DR: How DNA methylation, post-translational modifications of histone, and noncoding RNA function are affected and involved in HD pathogenesis and the therapeutic effects of hist one deacetylase inhibitors and DNA binding drugs on epigenetic modifications and neuropathological sequelae in HD are discussed.
Journal ArticleDOI
p53-dependent SIRT6 expression protects Aβ42-induced DNA damage.
Eun Sun Jung,Hyunjung Choi,Hyundong Song,Yu Jin Hwang,Ahbin Kim,Hoon Ryu,Hoon Ryu,Inhee Mook-Jung +7 more
TL;DR: It is revealed that p53-dependent SIRT6 expression protects cells from Aβ42-induced DNA damage, making SIRT 6 a promising new therapeutic target for the treatment of AD.