J
Joo Y. Lee
Researcher at Gwangju Institute of Science and Technology
Publications - 40
Citations - 5439
Joo Y. Lee is an academic researcher from Gwangju Institute of Science and Technology. The author has contributed to research in topics: Signal transduction & TLR4. The author has an hindex of 27, co-authored 40 publications receiving 5033 citations. Previous affiliations of Joo Y. Lee include University of California, Davis & Catholic University of Korea.
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Journal ArticleDOI
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.
TL;DR: A novel mechanism by which fatty acids modulate signaling pathways and target gene expression is represented by both SFA-induced COX-2 expression and its inhibition by UFAs are mediated through a common signaling pathway derived from Tlr4.
Journal ArticleDOI
Differential modulation of Toll-like receptors by fatty acids preferential inhibition by n-3 polyunsaturated fatty acids
Joo Y. Lee,Anthony Plakidas,Won H. Lee,Anne Heikkinen,Prithiva Chanmugam,George A. Bray,Daniel H. Hwang +6 more
TL;DR: Results demonstrate that inhibition of COX-2 expression by n-3 PUFAs is mediated through the modulation of TLR-mediated signaling pathways, and the beneficial or detrimental effects of different types of dietary fatty acids on the risk of the development of many chronic inflammatory diseases may be in part mediated throughThe modulation ofTLRs.
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Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1
Joo Y. Lee,Ling Zhao,Hyung S. Youn,Amy R. Weatherill,Richard I. Tapping,Lili Feng,Won H. Lee,Katherine A. Fitzgerald,Daniel H. Hwang +8 more
TL;DR: It is demonstrated that lauric acid activates TLR2 dimers as well as TLR4 for which respective bacterial agonists require acylated fatty acids, whereas DHA inhibits the activation of all TLRs tested.
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Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids.
Joo Y. Lee,Jianping Ye,Zhanguo Gao,Hyung S. Youn,Won H. Lee,Ling Zhao,Nywana Sizemore,Daniel H. Hwang +7 more
TL;DR: The results suggest that saturated and polyunsaturated fatty acids reciprocally modulate the activation of TLR4 and its downstream signaling pathways involving MyD88/IRAK/TRAF6 and PI3K/AKT and further suggest the possibility thatTLR4-mediated target gene expression and cellular responses are also differentially modulated by saturated and uns saturated fatty acids.
Journal ArticleDOI
Saturated and Polyunsaturated Fatty Acids Reciprocally Modulate Dendritic Cell Functions Mediated through TLR4
TL;DR: The results presented in this study demonstrate that the saturated fatty acid, lauric acid, up-regulates the expression of costimulatory molecules, MHC class II, and cytokines in bone marrow-derived DCs, implying that TLRs are involved in sterile inflammation and immune responses induced by nonmicrobial endogenous molecules.