R
Richard I. Tapping
Researcher at University of Illinois at Urbana–Champaign
Publications - 62
Citations - 6366
Richard I. Tapping is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Receptor & Innate immune system. The author has an hindex of 35, co-authored 62 publications receiving 6027 citations. Previous affiliations of Richard I. Tapping include McMaster University & Scripps Research Institute.
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Journal ArticleDOI
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.
Catherine Werts,Catherine Werts,Richard I. Tapping,John C. Mathison,Tsung-Hsien Chuang,Vladimir V. Kravchenko,Isabelle Saint Girons,David A. Haake,Paul J. Godowski,Fumitaka Hayashi,Adrian Ozinsky,David M. Underhill,Carsten J. Kirschning,Hermann Wagner,Alan Aderem,Peter S. Tobias,Richard J. Ulevitch +16 more
TL;DR: It is shown that for intact L. interrogans, it is LPS, not lipoprotein, that constitutes the predominant signaling component for macrophages through a TLR2 pathway, providing a basis for understanding the innate immune response caused by leptospirosis.
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BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
Yutaka Kato,Vladimir V. Kravchenko,Richard I. Tapping,Jiahuai Han,Richard J. Ulevitch,Jiing Dwan Lee +5 more
TL;DR: A constitutively active form of the MAP kinase kinase, MEK5(D), is described, which selectively activates BMK1 but not other MAP kinases in vivo, and results strongly suggest that in some cell types theMEK5/BMK1 MAP Kinase signaling pathway regulates serum‐induced early gene expression through the transcription factor MEF2C.
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Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1
Joo Y. Lee,Ling Zhao,Hyung S. Youn,Amy R. Weatherill,Richard I. Tapping,Lili Feng,Won H. Lee,Katherine A. Fitzgerald,Daniel H. Hwang +8 more
TL;DR: It is demonstrated that lauric acid activates TLR2 dimers as well as TLR4 for which respective bacterial agonists require acylated fatty acids, whereas DHA inhibits the activation of all TLRs tested.
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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
Yutaka Kato,Richard I. Tapping,Shuang Huang,Mark H. Watson,Richard J. Ulevitch,Jiing Dwan Lee +5 more
TL;DR: It is demonstrated that Bmk1 is part of a distinct MAP-kinase signalling pathway that is required for EGF-induced cell proliferation and progression through the cell cycle.
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Toll-like Receptor 4, but Not Toll-Like Receptor 2, Is a Signaling Receptor for Escherichia and Salmonella Lipopolysaccharides
TL;DR: The results confirm recent findings that TLR4, but not TLR2, mediates cellular activation in response to LPS derived from both Escherichia coli and Salmonella minnesota and show thatTLR4 is the predominant signaling receptor for LPS in human whole blood.