Differential modulation of Toll-like receptors by fatty acids preferential inhibition by n-3 polyunsaturated fatty acids
Joo Y. Lee,Anthony Plakidas,Won H. Lee,Anne Heikkinen,Prithiva Chanmugam,George A. Bray,Daniel H. Hwang +6 more
TLDR
Results demonstrate that inhibition of COX-2 expression by n-3 PUFAs is mediated through the modulation of TLR-mediated signaling pathways, and the beneficial or detrimental effects of different types of dietary fatty acids on the risk of the development of many chronic inflammatory diseases may be in part mediated throughThe modulation ofTLRs.About:
This article is published in Journal of Lipid Research.The article was published on 2003-03-01 and is currently open access. It has received 531 citations till now. The article focuses on the topics: Saturated fatty acid & Polyunsaturated fatty acid.read more
Citations
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Macrophages, Inflammation, and Insulin Resistance
TL;DR: Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention.
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GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects
Da Young Oh,Saswata Talukdar,Eun Ju Bae,Takeshi Imamura,Hidetaka Morinaga,WuQiang Fan,Pingping Li,Wendell J. Lu,Steven M. Watkins,Jerrold M. Olefsky +9 more
TL;DR: GPR120 is a functional omega-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation.
Journal ArticleDOI
Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.
TL;DR: Overall, current data provide strong concordant evidence that n-3 PUFA are bioactive compounds that reduce risk of cardiac death.
Journal ArticleDOI
A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes Role of Free Fatty Acids and Tumor Necrosis Factor α
TL;DR: It is postulate that a paracrine loop involving FFAs and TNF-α between adipocytes and macrophages establishes a vicious cycle that aggravates inflammatory changes in the adipose tissue.
Journal ArticleDOI
Dietary factors and low-grade inflammation in relation to overweight and obesity
Philip C. Calder,Namanjeet Ahluwalia,Fred Brouns,Timo Buetler,Karine Clément,Karen Cunningham,Katherine Esposito,Lena S. Jönsson,Hubert Kolb,Mirian Lansink,Ascensión Marcos,Andrew N. Margioris,Nathan V. Matusheski,Herve Nordmann,John O’Brien,Giuseppe Pugliese,Salwa W. Rizkalla,Casper G. Schalkwijk,Jaakko Tuomilehto,Julia Wärnberg,Bernhard Watzl,Brigitte M. Winklhofer-Roob +21 more
TL;DR: Potential mechanisms are described and research gaps, which limit the understanding of the interaction between diet and postprandial and chronic low-grade inflammation, are identified.
References
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
Journal ArticleDOI
Toll-like receptors in the induction of the innate immune response
Alan Aderem,Richard J. Ulevitch +1 more
TL;DR: A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.
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Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
Charles E. Eberhart,Robert J. Coffey,Aramandla Radhika,Francis M. Giardiello,Suzanne Ferrenbach,Raymond N. DuBois +5 more
TL;DR: COX-2, but not COX-1, gene expression is markedly elevated in most human colorectal cancers compared with accompanying normal mucosa, and COx-2 expression seems to be increased in a subset of adenomas.