S
Scott K. Durum
Researcher at National Institutes of Health
Publications - 144
Citations - 10942
Scott K. Durum is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Receptor. The author has an hindex of 53, co-authored 136 publications receiving 10110 citations. Previous affiliations of Scott K. Durum include Science Applications International Corporation.
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Journal ArticleDOI
There is more than one interleukin 1.
TL;DR: The biochemical characteristics, gene cloning, cell sources, biological properties and actions of IL-1 are discussed, and reasons why this pleitotropic, nonspecific hormone-like cytokine is of considerable concern to immunologists are given.
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Interleukin-7 receptor expression: intelligent design
TL;DR: There is mounting evidence indicating that the amount of IL-7 receptor expressed on a cell not only determines how vigorously the cell responds toIL-7, but it can also determine how efficiently the cell consumes IL- 7 and, therefore, affect the supply of this limiting resource in the niche.
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Interleukin 1: an immunological perspective.
TL;DR: The immunological discovery of IL-l sprang from serendipitous findings during the course of early studies on suppressor T cells (Ts), when the possibility was being tested that Ts might suppress the mitogenic response of T cells stimulated by phytohemagglutinin (PHA).
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Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature
Pawel Muranski,Zachary A. Borman,Sid P. Kerkar,Christopher A. Klebanoff,Yun Ji,Luis Sanchez-Perez,Madhusudhanan Sukumar,Robert Reger,Zhiya Yu,Steven J. Kern,Rahul Roychoudhuri,Gabriela A. Ferreyra,Wei Shen,Scott K. Durum,Lionel Feigenbaum,Douglas C. Palmer,Paul A. Antony,Chi-Chao Chan,Arian Laurence,Robert L. Danner,Luca Gattinoni,Nicholas P. Restifo +21 more
TL;DR: Th17 cells, despite displaying low expression of CD27 and other phenotypic markers of terminal differentiation, efficiently eradicated tumors and caused autoimmunity, were long lived, and maintained a core molecular signature resembling early memory CD8(+) cells with stem cell-like properties.
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Stat5a/b are essential for normal lymphoid development and differentiation
Zhengju Yao,Yongzhi Cui,Wendy T. Watford,Jay H. Bream,Jay H. Bream,Kunihiro Yamaoka,Bruce D. Hissong,Denise Li,Scott K. Durum,Qiong Jiang,Avinash Bhandoola,Lothar Hennighausen,John J. O'Shea +12 more
TL;DR: It is shown that mice completely deficient in Stat5a/b have severely impaired lymphoid development and differentiation and results in severe combined immunodeficiency, similar in many respects to deficiency of IL-7R, gammac, and Jak3.