Urine in Clinical Proteomics
Stéphane Decramer,Stéphane Decramer,Anne Gonzalez de Peredo,Benjamin Breuil,Benjamin Breuil,Harald Mischak,Bernard Monsarrat,Jean-Loup Bascands,Jean-Loup Bascands,Joost P. Schanstra,Joost P. Schanstra +10 more
Reads0
Chats0
TLDR
Urine has evolved as one of the most attractive body fluids in clinical proteomics with potentially a rapid application in the clinic with potentially an era of validation of urinary biomarkers in larger prospective studies.About:
This article is published in Molecular & Cellular Proteomics.The article was published on 2008-10-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Biomarker discovery & Proteomics.read more
Citations
More filters
Journal ArticleDOI
Protein Analysis by Shotgun/Bottom-up Proteomics
TL;DR: The progress of proteomics has been driven by the development of new technologies for peptide/protein separation, mass spectrometry analysis, isotope labeling for quantification, and bioinformatics data analysis.
Journal ArticleDOI
Recommendations for Biomarker Identification and Qualification in Clinical Proteomics
Harald Mischak,Guenter Allmaier,Rolf Apweiler,Teresa K. Attwood,Marc Baumann,Ariela Benigni,Samuel E. Bennett,Rainer Bischoff,Erik Bongcam-Rudloff,Giovambattista Capasso,Joshua J. Coon,Patrick C. D'Haese,Anna F. Dominiczak,Mohammed Dakna,Hassan Dihazi,Jochen H. H. Ehrich,Patricia Fernández-Llama,Danilo Fliser,Jørgen Frøkiær,Jérôme Garin,Mark Girolami,William S. Hancock,Marion Haubitz,Denis F. Hochstrasser,Rury R. Holman,John P. A. Ioannidis,Joachim Jankowski,Bruce A. Julian,Jon B. Klein,Walter Kolch,Theo M. Luider,Ziad A. Massy,William B. Mattes,Franck Molina,Bernard Monsarrat,Jan Novak,Karlheinz Peter,Peter Rossing,Marta Sanchez-Carbayo,Joost P. Schanstra,O. John Semmes,Goce Spasovski,Dan Theodorescu,Visith Thongboonkerd,Raymond Vanholder,Timothy D. Veenstra,Eva M. Weissinger,Tadashi Yamamoto,Antonia Vlahou +48 more
TL;DR: It is asserted that successful studies generally use suitable statistical approaches for biomarker definition and confirm results in independent test sets and a brief set of practical and feasible recommendations are described for investigators to properly identify and qualify proteomic biomarkers, which could also be used as reporting requirements.
Journal ArticleDOI
An update on primary hyperoxaluria
TL;DR: The autosomal recessive inherited primary hyperoxalurias types I, II and III are caused by defects in glyoxylate metabolism that lead to the endogenous overproduction of oxalate, which results in recurrent urolithiasis and/or progressive nephrocalcinosis.
Journal ArticleDOI
Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC.
TL;DR: The results suggested that leucine‐rich α‐2‐glycoprotein (LRG1) may be a candidate biomarker for non‐invasive diagnosis of NSCLC in urine.
Journal ArticleDOI
Quantitative analysis of the intra- and inter-individual variability of the normal urinary proteome.
Nagarjuna Nagaraj,Matthias Mann +1 more
TL;DR: Determination of the normal fluctuation of individual urinary proteins should be useful in establishing significance thresholds in biomarker studies and allowed definition of a common and abundant set of 500 proteins that were readily detectable in all studied individuals.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
The Human Plasma Proteome History, Character, and Diagnostic Prospects
TL;DR: This work speculates on the reasons behind this large discrepancy between the expectations arising from proteomics and the realities of clinical diagnostics and suggests approaches by which protein-disease associations may be more effectively translated into diagnostic tools in the future.
Journal ArticleDOI
Resampling-Based Multiple Testing: Examples and Methods for p-Value Adjustment.
TL;DR: Resampling-Based Adjustments: Basic Concepts and Practical Applications.
Journal ArticleDOI
Identifying differentially expressed genes using false discovery rate controlling procedures
TL;DR: Three resampling-based FDR controlling procedures are presented, that account for the test statistics distribution, and their performance is compared to that of the naïve application of the linear step-up procedure in Benjamini and Hochberg (1995), and the highest power is achieved, at the expense of a more sophisticated algorithm, by the resamplings-based procedures that resample the joint distribution of the testStatistics and estimate the level of FDR control.
Journal ArticleDOI
Protein biomarker discovery and validation: the long and uncertain path to clinical utility.
TL;DR: Better understanding of the overall process of biomarker discovery and validation and of the challenges and strategies inherent in each phase should improve experimental study design, in turn increasing the efficiency of biomarkers development and facilitating the delivery and deployment of novel clinical tests.
Related Papers (5)
Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease
David M. Good,Petra Zürbig,Àngel Argilés,Hartwig W. Bauer,Georg M. N. Behrens,Joshua J. Coon,Mohammed Dakna,Stéphane Decramer,Christian Delles,Anna F. Dominiczak,Jochen H. H. Ehrich,Frank Eitner,Danilo Fliser,Moritz Frommberger,Arnold Ganser,Mark Girolami,Igor Golovko,Wilfried Gwinner,Marion Haubitz,Stefan Herget-Rosenthal,Joachim Jankowski,Holger Jahn,George Jerums,Bruce A. Julian,Markus Kellmann,Volker Kliem,Walter Kolch,Andrzej S. Krolewski,Andrzej S. Krolewski,Mario Luppi,Ziad A. Massy,Michael Melter,Christian Neusüss,Jan Novak,Karlheinz Peter,Kasper Rossing,Harald D. Rupprecht,Joost P. Schanstra,Eric Schiffer,Jens-Uwe Stolzenburg,Lise Tarnow,Dan Theodorescu,Visith Thongboonkerd,Raymond Vanholder,Eva M. Weissinger,Harald Mischak,Philippe Schmitt-Kopplin +46 more