J
Jan Novak
Researcher at University of Alabama at Birmingham
Publications - 362
Citations - 19039
Jan Novak is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Nephropathy & Medicine. The author has an hindex of 70, co-authored 320 publications receiving 16150 citations. Previous affiliations of Jan Novak include Masaryk University & Mahidol University.
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Journal ArticleDOI
Glycosylation in health and disease.
TL;DR: The broad role of glycans in immunity, cancer, xenotransplantation and glomerular filtration and the potential of ‘glycomedicine’ are discussed.
Journal ArticleDOI
The Pathophysiology of IgA Nephropathy
Hitoshi Suzuki,Krzysztof Kiryluk,Jan Novak,Zina Moldoveanu,Andrew B. Herr,Matthew B. Renfrow,Robert J. Wyatt,Francesco Scolari,Jiri Mestecky,Ali G. Gharavi,Bruce A. Julian +10 more
TL;DR: Recent advances in understanding the biochemical, immunologic, and genetic pathogenesis of IgA nephropathy are discussed, and five distinct susceptibility loci are identified that potentially influence these processes and contain candidate mediators of disease.
Journal ArticleDOI
Genome-wide association study identifies susceptibility loci for IgA nephropathy
Ali G. Gharavi,Krzysztof Kiryluk,Murim Choi,Yifu Li,Ping Hou,Ping Hou,Jingyuan Xie,Jingyuan Xie,Simone Sanna-Cherchi,Clara J. Men,Bruce A. Julian,Robert J. Wyatt,Jan Novak,John Cijiang He,Haiyan Wang,Jicheng Lv,Li Zhu,Weiming Wang,Zhaohui Wang,Kasuhito Yasuno,Murat Gunel,Shrikant Mane,Sheila Umlauf,Irina Tikhonova,Isabel Beerman,Silvana Savoldi,Riccardo Magistroni,Gian Marco Ghiggeri,Monica Bodria,Francesca Lugani,Francesca Lugani,Pietro Ravani,Claudio Ponticelli,Landino Allegri,Giuliano Boscutti,Giovanni M. Frascà,Alessandro Amore,Licia Peruzzi,Rosanna Coppo,Claudia Izzi,Battista Fabio Viola,Prati E,Maurizio Salvadori,Renzo Mignani,Loreto Gesualdo,Francesca Bertinetto,Paola Mesiano,Antonio Amoroso,Francesco Scolari,Nan Chen,Hong Zhang,Richard P. Lifton +51 more
TL;DR: Three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance, explain 4–7% of the disease variance and up to a tenfold variation in interindividual risk.
Journal ArticleDOI
Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease
David M. Good,Petra Zürbig,Àngel Argilés,Hartwig W. Bauer,Georg M. N. Behrens,Joshua J. Coon,Mohammed Dakna,Stéphane Decramer,Christian Delles,Anna F. Dominiczak,Jochen H. H. Ehrich,Frank Eitner,Danilo Fliser,Moritz Frommberger,Arnold Ganser,Mark Girolami,Igor Golovko,Wilfried Gwinner,Marion Haubitz,Stefan Herget-Rosenthal,Joachim Jankowski,Holger Jahn,George Jerums,Bruce A. Julian,Markus Kellmann,Volker Kliem,Walter Kolch,Andrzej S. Krolewski,Andrzej S. Krolewski,Mario Luppi,Ziad A. Massy,Michael Melter,Christian Neusüss,Jan Novak,Karlheinz Peter,Kasper Rossing,Harald D. Rupprecht,Joost P. Schanstra,Eric Schiffer,Jens-Uwe Stolzenburg,Lise Tarnow,Dan Theodorescu,Visith Thongboonkerd,Raymond Vanholder,Eva M. Weissinger,Harald Mischak,Philippe Schmitt-Kopplin +46 more
TL;DR: The establishment of a reproducible, high resolution method for peptidome analysis of naturally occurring human urinary peptides and proteins, ranging from 800 to 17,000 Da, using samples from 3,600 individuals analyzed by capillary electrophoresis coupled to MS is reported.
Journal ArticleDOI
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
Krzysztof Kiryluk,Yifu Li,Francesco Scolari,Simone Sanna-Cherchi,Murim Choi,Miguel Verbitsky,David Fasel,Sneh Lata,Sindhuri Prakash,Samantha Shapiro,Clara Fischman,Holly J. Snyder,Gerald B. Appel,Claudia Izzi,Battista Fabio Viola,Nadia Dallera,Lucia Del Vecchio,Cristina Barlassina,Erika Salvi,Francesca Bertinetto,Antonio Amoroso,Silvana Savoldi,Marcella Rocchietti,Alessandro Amore,Licia Peruzzi,Rosanna Coppo,Maurizio Salvadori,Pietro Ravani,Riccardo Magistroni,Gian Marco Ghiggeri,Gianluca Caridi,Monica Bodria,Francesca Lugani,Landino Allegri,Marco Delsante,Mariarosa Maiorana,Andrea Magnano,Giovanni M. Frascà,Emanuela Boer,Giuliano Boscutti,Claudio Ponticelli,Renzo Mignani,Carmelita Marcantoni,Domenico Di Landro,Domenico Santoro,Antonello Pani,Rosaria Polci,Sandro Feriozzi,Silvana Chicca,Marco Galliani,Maddalena Gigante,Loreto Gesualdo,Pasquale Zamboli,Giovanni Giorgio Battaglia,Maurizio Garozzo,Dita Maixnerova,Vladimir Tesar,Frank Eitner,Thomas Rauen,Jürgen Floege,Tibor Kovács,Judit Nagy,Krzysztof Mucha,Leszek Pączek,Marcin Zaniew,Małgorzata Mizerska-Wasiak,Maria Roszkowska-Blaim,Krzysztof Pawlaczyk,Daniel P. Gale,Jonathan Barratt,Lise Thibaudin,François Berthoux,Guillaume Canaud,Anne Boland,Marie Metzger,Ulf Panzer,Hitoshi Suzuki,Shin Goto,Ichiei Narita,Yasar Caliskan,Jingyuan Xie,Ping Hou,Nan Chen,Hong Zhang,Robert J. Wyatt,Jan Novak,Bruce A. Julian,John Feehally,Bénédicte Stengel,Daniele Cusi,Richard P. Lifton,Ali G. Gharavi +91 more
TL;DR: A genome-wide association study of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry is performed, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.