J
Jordyn Stuart
Researcher at University of Sydney
Publications - 25
Citations - 1635
Jordyn Stuart is an academic researcher from University of Sydney. The author has contributed to research in topics: Cannabinoid & Endocannabinoid system. The author has an hindex of 18, co-authored 25 publications receiving 1309 citations. Previous affiliations of Jordyn Stuart include Australian School of Advanced Medicine & Macquarie University.
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Journal ArticleDOI
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Marjolein Soethoudt,Uwe Grether,Juergen Fingerle,Travis W. Grim,Filomena Fezza,Luciano De Petrocellis,Christoph Ullmer,Benno Rothenhäusler,Camille Perret,Noortje van Gils,David B. Finlay,Christa MacDonald,Andrea Chicca,Marianela Dalghi Gens,Jordyn Stuart,Henk de Vries,Nicolina Mastrangelo,Lizi Xia,Georgios Alachouzos,Marc P. Baggelaar,Andrea Martella,Elliot D. Mock,Hui Deng,Laura H. Heitman,Mark Connor,Vincenzo Di Marzo,Jürg Gertsch,Aron H. Lichtman,Mauro Maccarrone,Pal Pacher,Michelle Glass,Mario van der Stelt +31 more
TL;DR: The most extensive characterization of the molecular pharmacology of the most widely used CB2R ligands to date is reported, identifying marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects.
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Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues.
Samuel D. Banister,Mitchell Longworth,Richard C. Kevin,Shivani Sachdev,Marina Santiago,Jordyn Stuart,James B. C. Mack,Michelle Glass,Iain S. McGregor,Mark Connor,Michael Kassiou +10 more
TL;DR: In vitro and in vivo data indicate that these SCs act as highly efficacious CB receptor agonists with greater potency than Δ(9)-THC and earlier generations of SCs.
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Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA
Samuel D. Banister,Samuel D. Banister,Michael Moir,Jordyn Stuart,Richard C. Kevin,Katie Wood,Mitchell Longworth,Shane M. Wilkinson,Corinne Beinat,Corinne Beinat,Alexandra S. Buchanan,Michelle Glass,Mark Connor,Iain S. McGregor,Michael Kassiou +14 more
TL;DR: Synthetic cannabinoid designer drugs based on indole and indazole scaffolds and featuring l-valinamide or l-tert-leucinamide side chains and several analogues are synthesized and characterized, indicating that these SCs are cannabimimetic in vivo, consistent with anecdotal reports of psychoactivity in humans.
Journal ArticleDOI
Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135
Samuel D. Banister,Jordyn Stuart,Richard C. Kevin,Amelia R. Edington,Mitchell Longworth,Shane M. Wilkinson,Corinne Beinat,Alexandra S. Buchanan,David E. Hibbs,Michelle Glass,Mark Connor,Iain S. McGregor,Michael Kassiou +12 more
TL;DR: In vitro functional activities of SC designer drugs JWH-018, UR-144, PB-22, and APICA, and their respective terminally fluorinated analogues and in vivo in vivo cannabinoid type 1 receptor binding affinity evaluated in rats showed no consistent trend for increased potency of fluorinated SCs over the corresponding des-fluoro SCs in vivo.
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The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.
Heather B. Bradshaw,Neta Rimmerman,Sherry Shu Jung Hu,Valery M. Benton,Jordyn Stuart,Kim Masuda,Benjamin F. Cravatt,David K. O’Dell,J. Michael Walker +8 more
TL;DR: The hypothesis that the signaling lipid NAGly is a metabolic product of AEA by both oxidative metabolism of the AEA ethanolamine moiety and through the conjugation of glycine to AA that is released during AEA hydrolysis by FAAH is supported.