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Jorge A. R. Salvador

Researcher at University of Coimbra

Publications -  136
Citations -  2715

Jorge A. R. Salvador is an academic researcher from University of Coimbra. The author has contributed to research in topics: Catalysis & Ring (chemistry). The author has an hindex of 27, co-authored 129 publications receiving 2336 citations. Previous affiliations of Jorge A. R. Salvador include University of York & Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa.

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Anticancer steroids: linking natural and semi-synthetic compounds

Jorge A. R. Salvador, +6 more
- 16 Jan 2013 - 
TL;DR: This review encompasses the most relevant discoveries on steroid anticancer drugs and leads through the last decade and comprises 668 references.
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Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity.

Rita Santos, +3 more
- 01 Sep 2009 - 
TL;DR: A series of new imidazole carboxylic esters (carbamates) and N-acylimidazoles derivatives of betulin and betulinic acid (14-29) have been synthesized and the vast majority has shown a better cytotoxicity profile than betulinIC acid, including the betulin derivatives.
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Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

Judite R M Coimbra, +7 more
- 24 May 2018 - 
TL;DR: The aim of this review is to highlight the progress in the discovery of potent and selective small molecule BACE1 inhibitors over the past decade.
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Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

Jorge A. R. Salvador, +4 more
- 06 Nov 2012 - 
TL;DR: This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects.
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Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment

Jorge A. R. Salvador, +7 more
- 14 Jul 2017 - 
TL;DR: A number of semisynthetic derivatives of oleanane-, ursane- and quinone methide friedelane-type PTs with anticancer activity have been synthetized aiming to improve their therapeutic activity and pharmacokinetic properties, and decrease their toxicity.