J
Jørn Nerup
Researcher at Steno Diabetes Center
Publications - 180
Citations - 12907
Jørn Nerup is an academic researcher from Steno Diabetes Center. The author has contributed to research in topics: Diabetes mellitus & Islet. The author has an hindex of 60, co-authored 180 publications receiving 12646 citations. Previous affiliations of Jørn Nerup include Hvidovre Hospital & Memorial Hospital of South Bend.
Papers
More filters
Journal ArticleDOI
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Jeffrey C. Barrett,David Clayton,Patrick Concannon,Beena Akolkar,Jason D. Cooper,Henry A. Erlich,Cécile Julier,Grant Morahan,Jørn Nerup,Concepcion Nierras,Vincent Plagnol,Flemming Pociot,Helen Schuilenburg,Deborah J. Smyth,Helen Stevens,John A. Todd,Neil Walker,Stephen S. Rich +17 more
TL;DR: The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
Journal ArticleDOI
A Taql polymorphism in the human interleukin-1β (IL-1β) gene correlates with IL-1β secretion in vitro
TL;DR: It is concluded that the 13.4 kb allele represents an IL‐1β‘high‐secretor’ phenotype, that the observed RFLP may be a genetic susceptibility marker for IDDM in non‐DR3 and non-DR4 individuals and that high IL‐ 1β secretory capacity may be an pathogenic factor for ID DM in these patients.
Journal ArticleDOI
Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans.
Klaus Bendtzen,Thomas Mandrup-Poulsen,Jørn Nerup,Jens Høiriis Nielsen,Charles A. Dinarello,M. Svenson +5 more
TL;DR: Monocyte-derived pI 7 IL-1 may contribute to islet cell damage and therefore to the development of insulin-dependent diabetes mellitus.
Journal ArticleDOI
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-a and TNF-0 by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus
Flemming Pociot,Laurence Briant,Cornelis Jongeneel,J. Mølvig,Helle Worsaae,Michel Abbal,Mogens Thomsen,Jørn Nerup,Anne Cambon-Thomsen +8 more
TL;DR: In a group of DR3/DR4 heterozygous patients with insulin‐dependent diabetes mellitus (IDDM), the frequency of the TNFa2 allele was higher than in HLA‐DR matched controls, whereas theTNFa6 allele was more frequent in control individuals.
Journal ArticleDOI
Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans
Thomas Mandrup-Poulsen,Klaus Bendtzen,Jørn Nerup,Charles A. Dinarello,M. Svenson,Jens Høiriis Nielsen +5 more
TL;DR: It is suggested that Interleukin-1 may play an important role in the molecular mechanisms underlying autoimmune B-cell destruction leading to Type 1 (insulin-dependent) diabetes mellitus.