J
Josa M. Frischer
Researcher at Medical University of Vienna
Publications - 51
Citations - 4236
Josa M. Frischer is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 16, co-authored 45 publications receiving 3381 citations.
Papers
More filters
Journal ArticleDOI
The relation between inflammation and neurodegeneration in multiple sclerosis brains
Josa M. Frischer,Stephan Bramow,Assunta Dal-Bianco,Claudia F. Lucchinetti,Helmut Rauschka,Manfred Schmidbauer,Henning Laursen,Per Soelberg Sørensen,Hans Lassmann +8 more
TL;DR: It is found that pronounced inflammation in the brain is not only present in acute and relapsing multiple sclerosis but also in the secondary and primary progressive disease, and the disease processes of multiple sclerosis may die out in aged patients with long-standing disease.
Journal ArticleDOI
Oxidative damage in multiple sclerosis lesions
Lukas Haider,Marie Therese Fischer,Josa M. Frischer,Jan Bauer,Romana Höftberger,Gergö Botond,Harald Esterbauer,Christoph J. Binder,Christoph J. Binder,Joseph L. Witztum,Hans Lassmann +10 more
TL;DR: The data suggest profound oxidative injury of oligodendrocytes and neurons to be associated with active demyelination and axonal or neuronal injury in multiple sclerosis.
Journal ArticleDOI
Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque.
Josa M. Frischer,Stephen D. Weigand,Yong Guo,Nilufer Kale,Joseph E. Parisi,Istvan Pirko,Jay Mandrekar,Stephan Bramow,Imke Metz,Wolfgang Brück,Hans Lassmann,Claudia F. Lucchinetti +11 more
TL;DR: An extensive analysis of white matter plaques in a large sample of multiple sclerosis autopsies provides insights into the dynamic nature of MS pathology.
Journal ArticleDOI
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
Marie Therese Fischer,Rakhi Sharma,Jamie L. Lim,Lukas Haider,Josa M. Frischer,Joost A. R. Drexhage,Don J. Mahad,Monika Bradl,Jack van Horssen,Hans Lassmann +9 more
TL;DR: The data suggest that the inflammation-associated oxidative burst in activated microglia and macrophages plays an important role in demyelination and free radical-mediated tissue injury in the pathogenesis of multiple sclerosis.
Journal ArticleDOI
Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron
Lukas Haider,Constantina Simeonidou,Günther Steinberger,Simon Hametner,Nikolaos Grigoriadis,Georgia Deretzi,Gabor G. Kovacs,Alexandra Kutzelnigg,Hans Lassmann,Josa M. Frischer +9 more
TL;DR: Both focal lesions as well as diffuse neurodegeneration in the deep grey matter appeared to contribute to the neurological disabilities of MS patients.