Imke Metz

TL;DR: This study provides an overview of the clinical and paraclinical features of NMOSD in Caucasians and demonstrates a number of distinct disease characteristics in seropositive and seronegative patients.

TL;DR: An extensive analysis of white matter plaques in a large sample of multiple sclerosis autopsies provides insights into the dynamic nature of MS pathology.

TL;DR: Although lesion size >5 cm was associated with a slightly higher EDSS at last follow-up, long-term prognosis in patients with disease duration >10 years was better compared with a population-based multiple sclerosis cohort matched for disease duration (EDSS 3.5; P < 0.001).

TL;DR: Antibodies to MOG can be found in a distinct subgroup of adult patients with clinically definite multiple sclerosis with a specific clinical phenotype and may indicate disease heterogeneity.

TL;DR: The data demonstrate that the occurrence of microglial nodules is not specific to MS and is associated with degenerating as well as damaged axons in early MS, and show that early MS microglia/macrophages exhibit both pro- and antiinflammatory phenotypes.