J
Josbert J. Keller
Researcher at Leiden University Medical Center
Publications - 45
Citations - 5333
Josbert J. Keller is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 36 publications receiving 4378 citations.
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Journal ArticleDOI
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
Els van Nood,A. Vrieze,Max Nieuwdorp,Susana Fuentes,Erwin G. Zoetendal,Willem M. de Vos,Caroline E. Visser,Ed J. Kuijper,Peter Speelman,Josbert J. Keller +9 more
TL;DR: The infusion of donor feces was significantly more effective for the treatment of recurrent C. difficile infection than the use of vancomycin and patients showed increased fecal bacterial diversity, similar to that in healthy donors, with an increase in Bacteroidetes species and clostridium clusters IV and XIVa and a decrease in Proteobacteria species.
Journal ArticleDOI
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.
Gijs R. van den Brink,Sylvia A. Bleuming,James C. H. Hardwick,Berber L Schepman,G. Johan A. Offerhaus,Josbert J. Keller,Corinne M. Nielsen,William Gaffield,Sander J. H. van Deventer,Drucilla J. Roberts,Maikel P. Peppelenbosch +10 more
TL;DR: In this article, the authors reported that Indian hedgehog (Ihh) is expressed by mature colonocytes and regulates their differentiation in vitro and in vivo, and they identified a new Wnt-Hh axis in colonic epithelial renewal.
Journal ArticleDOI
Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.
James C. H. Hardwick,Gijs R. van den Brink,Sylvia A. Bleuming,Isabel Ballester,Jan M. H. van den Brande,Josbert J. Keller,G. Johan A. Offerhaus,Sander J. H. van Deventer,Maikel P. Peppelenbosch +8 more
TL;DR: These data suggest that BMP2 acts as a tumor suppressor promoting apoptosis in mature colonic epithelial cells.
Journal ArticleDOI
Relative frequency and morphology of cancers in STK11 mutation carriers.
Wendy Lim,Sylviane Olschwang,Josbert J. Keller,Anne Marie Westerman,Fred H. Menko,Lisa A. Boardman,Rodney J. Scott,Jill D. Trimbath,Francis M. Giardiello,Stephen B. Gruber,Johan J.P. Gille,G. Johan A. Offerhaus,Felix W. M. de Rooij,J. H. Paul Wilson,Allan D. Spigelman,Robin Kenneth Stewart Phillips,Richard S. Houlston +16 more
TL;DR: In this article, the authors quantitatively show the spectrum of cancer risk associated with STK11 mutations in the context of Peutz-Jeghers syndrome (PJS) and provide a valuable reference for defining surveillance regimens.
Journal ArticleDOI
Fecal Microbiota Transplantation in Neurological Disorders.
Karuna E. W. Vendrik,Rogier E. Ooijevaar,Rogier E. Ooijevaar,Pieter R. C. de Jong,Jon D. Laman,Bob W. van Oosten,Jacobus J. van Hilten,Quinten R Ducarmon,Josbert J. Keller,E.J. Kuijper,Maria Fiorella Contarino +10 more
TL;DR: Preliminary literature suggests that FMT may be a promising treatment option for several neurological disorders, however, available evidence is still scanty and some contrasting results were observed.