Jose Barrera

TL;DR: Yorkie (Yki), the Drosophila ortholog of the mammalian transcriptional coactivator yes-associated protein (YAP), is identified as a missing link between Wts and transcriptional regulation and is a critical target of the Wts/Lats protein kinase and a potential oncogene.

TL;DR: It is shown that CDK5RAP2 loss of function in mice causes centriole amplification with a preponderance of single, unpaired centrioles and increased numbers of daughter-daughter centriola pairs, which indicates thatCDK5 RAP2 is required to maintain centriol engagement and cohesion, thereby restricting centriose replication.

TL;DR: It is shown that CRP transgenic mice and wild-type mice administered recombinant CRP are insulin resistant and CRP causes insulin resistance in mice through FcγRIIB-mediated inhibition of skeletal muscle glucose delivery.

TL;DR: CE + BZA affords protection from diet-induced adiposity, hepatic steatosis, and insulin resistance with minimal impact on the female reproductive tract in mice and may provide a valuable new means to favorably regulate body composition and glucose homeostasis and combat fatty liver.

TL;DR: Although nonnuclear ER activation does not prevent atherosclerosis or diet-induced obesity or glucose intolerance, EDC may provide a potential new strategy to combat hepatic steatosis without impacting the female reproductive tract or increasing cancer risk.