J
Josef Donnerer
Researcher at Medical University of Graz
Publications - 116
Citations - 5180
Josef Donnerer is an academic researcher from Medical University of Graz. The author has contributed to research in topics: Substance P & Capsaicin. The author has an hindex of 39, co-authored 116 publications receiving 5089 citations. Previous affiliations of Josef Donnerer include Austrian Academy of Sciences & Janssen Pharmaceutica.
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Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo.
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
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Inhibition of neurogenic vasodilatation and plasma extravasation by substance P antagonists, somatostatin and [D-Met2, Pro5]enkephalinamide
TL;DR: The results further support the concepts that neurogenic vasodilatation and plasma extravasation are mediated by SP, and that somatostatin and opiates inhibit the release of SP from peripheral sensory nerve endings.
Journal ArticleDOI
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
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Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis
TL;DR: Capsaicin (20-80 mg/kg, s.c.) reduced the inflammatory response to inoculation with Mycobacterium butyricum in the rat and attenuated the increase in substance P content in sciatic nerve, saphenous nerve, dorsal root ganglia, dorsal roots, and dorsal spinal cord which occurs in rats with adjuvant arthritis.
Journal ArticleDOI
Increase of substance P in primary afferent nerves during chronic pain
Fred Lembeck,Fred Lembeck,Fred Lembeck,Josef Donnerer,Josef Donnerer,Josef Donnerer,F.C. Colpaert,F.C. Colpaert,F.C. Colpaert +8 more
TL;DR: Substance P was found to be increased in the sciatic nerve of rats suffering chronic pain due to adjuvant-induced polyarthritis, and this increase in primary afferents is assumed to reflect adaptive changes initiated by chronic noxious events such as inflammation.