J
Josef Jampilek
Researcher at Comenius University in Bratislava
Publications - 331
Citations - 6091
Josef Jampilek is an academic researcher from Comenius University in Bratislava. The author has contributed to research in topics: Lipophilicity & Chemistry. The author has an hindex of 36, co-authored 303 publications receiving 4695 citations. Previous affiliations of Josef Jampilek include Palacký University, Olomouc & Slovak Academy of Sciences.
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Journal ArticleDOI
Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents
TL;DR: Design and synthesis of twelve novel compounds bearing primaquine motif and hydroxy- or halogenamine linked by an urea or bis-urea spacer are described and three active compounds against Mycobacterium marinum and M. tuberculosis are detected.
Journal ArticleDOI
Investigating the activity of 2-substituted alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as skin penetration enhancers.
Katerina Brychtova,Radka Opatrilova,Ivan Raich,Danuta S. Kalinowski,Lenka Dvorakova,Lukas Placek,Jozef Csöllei,Des R. Richardson,Josef Jampilek +8 more
TL;DR: Two series of esters were generated by multi-step synthesis with substituted 6-aminohexanoic acid as potential transdermal penetration enhancers and showed higher enhancement ratios than oleic acid and showed minimal anti-proliferative activity, indicating they would have low cytotoxicity when administered as chemical penetration enhancer.
Journal ArticleDOI
Preparation and properties of new co-crystals of ibandronate with gluco- or galactopyranoside derivatives.
Zbynek Oktabec,Jiri Kos,Zuzana Mandelova,Lenka Havelkova,Tomáš Pekárek,Anna Rezacova,Lukas Placek,Marcela Tkadlecova,Jaroslav Havlicek,Jiri Dohnal,Josef Jampilek +10 more
TL;DR: The relationships between the chemical structures of the studied compounds required for co-crystal generation are discussed and new entities of ibandronate monosodium salt with phenyl-β-d-galactopyranoside were found and characterized.
Book ChapterDOI
Bioactivity of Nanoformulated Synthetic and Natural Insecticides and Their Impact on Environment
TL;DR: This chapter gives a comprehensive overview of recent findings related to the bioactivity of nanoformulations of synthetic and natural insecticides against harmful insects causing severe damage to economically important crops or deteriorating stored food products.
Journal ArticleDOI
Investigation of substituted 6-aminohexanoates as skin penetration enhancers.
Katerina Brychtova,Lenka Dvorakova,Radka Opatrilova,Ivan Raich,Sandra Kacerova,Lukas Placek,Danuta S. Kalinowski,Des R. Richardson,Josef Jampilek +8 more
TL;DR: All of the investigated agents demonstrated minimal anti-proliferative activity using the SK-N-MC neuroepithelioma cell line, suggesting these analogs would have a low cytotoxic profile when administered in vivo as chemical penetration enhancers.