J
Josef Jampilek
Researcher at Comenius University in Bratislava
Publications - 331
Citations - 6091
Josef Jampilek is an academic researcher from Comenius University in Bratislava. The author has contributed to research in topics: Lipophilicity & Chemistry. The author has an hindex of 36, co-authored 303 publications receiving 4695 citations. Previous affiliations of Josef Jampilek include Palacký University, Olomouc & Slovak Academy of Sciences.
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Journal ArticleDOI
Activity of ring-substituted 8-hydroxyquinoline-2-carboxanilides against intestinal sulfate-reducing bacteria Desulfovibrio piger
TL;DR: The antibacterial efficacy of the most active C’(3)-substituted compounds practically did not change with increasing compound lipophilicity, indicating that this position of substitution is favorable for significant antimicrobial effect.
Journal ArticleDOI
Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers.
Lech Mrózek,Lenka Dvořáková,Zuzana Mandelova,Lucie Rárová,Anna Řezáčová,Lukas Placek,Radka Opatřilová,Jiří Dohnal,Oldřich Paleta,Vladimír Král,Pavel Drašar,Josef Jampilek +11 more
TL;DR: Most of the target compounds showed minimal anti-proliferative activity (IC(50)>37 μM), indicating they would have low cytotoxicity when administered as chemical absorption modifiers.
Journal ArticleDOI
Ring-substituted 8-hydroxyquinoline-2-carboxanilides as potential antimycobacterial agents.
Jiri Kos,Iveta Zadrazilova,Eoghan Nevin,Michal Šoral,Tomas Gonec,Peter Kollar,Michal Oravec,Aidan Coffey,Jim O'Mahony,Tibor Liptaj,Katarina Kralova,Josef Jampilek +11 more
TL;DR: In this study, a series of twenty-two ring-substituted 8-hydroxyquinoline-2-carboxanilides was prepared and characterized and some of the tested compounds showed the antimycobacterial activity against M. paratuberculosis comparable with or higher than that of rifampicin.
Journal ArticleDOI
Sulfolane: Magic Extractor or Bad Actor? Pilot-Scale Study on Solvent Corrosion Potential
TL;DR: In this paper, a comprehensive review focusing mainly on the state-of-the-art aspects of the sulfolane synthesis, application of sulfolanes as an extractive solvent due to its unique physicochemical properties as well as the potential of sulfolsane to cause equipment corrosion and subsequent spills is presented.
Book ChapterDOI
Application of Nanobioformulations for Controlled Release and Targeted Biodistribution of Drugs
Josef Jampilek,Katarina Kralova +1 more
TL;DR: In this paper, the authors focus on natural-based biocompatible and biodegradable materials that are used as matrices/carriers for controlled release or targeted biodistribution of nanoscale active pharmaceutical ingredients with low toxicity and favorable pharmacokinetics.