Josef Jampilek

TL;DR: The data suggest that the ability to inhibit the proliferation of THP-1 or MCF-7 cells might be referred to meta- or para-substituted derivatives with electron-withdrawing groups -F, -Br, or -CF3 at anilide moiety, and their structure merits further investigation as a model moiety of new small-molecule compounds with potential anticancer properties.

TL;DR: Compounds with insufficient solubility carry a higher risk of failure during discovery and development, since insufficientsolubility may compromise other property assays, mask additional undesirable properties, influence both pharmacokinetic and pharmacodynamic properties of the compound and finally may affect the developability of the compounds.

TL;DR: A new solid phase of risedronate monosodium salt generated in the presence of phenyl-β-D-galactopyranoside under thermodynamically controlled crystallization conditions was found and characterized using solid state NMR spectroscopy, X-ray powder diffraction and differential scanning calorimetry.

TL;DR: A series of 14 target benzyl [2-(arylsulfamoyl)-1-substituted-ethyl] carbamates was prepared by multi-step synthesis and characterized.

TL;DR: Screening of the cytotoxicity of the most effective compounds was performed using human monocytic leukemia THP-1 cells, and based on LD50 values, it can be stated that the compounds have insignificant toxicity against human cells.