J
Joseph Huppert
Researcher at French Institute of Health and Medical Research
Publications - 4
Citations - 60
Joseph Huppert is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cytotoxic T cell & Antibody. The author has an hindex of 4, co-authored 4 publications receiving 60 citations.
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Journal ArticleDOI
Characterization of two murine monoclonal antibodies (P10, P12) directed against different determinants on human blood platelet thrombospondin.
Philippe Clézardin,John L. McGregor,John L. McGregor,Monique Lyon,Kenneth J. Clemetson,Joseph Huppert +5 more
TL;DR: Results indicate that thrombospondin is probably degraded by the endogenous platelet calcium-dependent protease.
Journal ArticleDOI
Depression of reverse transcriptase activity by hybridoma supernatants: a potential problem in screening for retroviral contamination.
Monique Lyon,Joseph Huppert +1 more
TL;DR: This work measured reverse transcriptase activity in the supernatant of some 30 hybridoma lines of murine origin and found that the observed activity expressed as pmoles of [3H]-dGMP incorporated into an acid insoluble polymer, is frequently much lower than would be expected from the amount of retrovirus seen by electron microscopy in the corresponding cells.
Journal Article
Effect of Doxorubicin on Mouse Hybridoma B Cells: Stimulation of Immunoglobulin Synthesis and Secretion
TL;DR: The data suggest that doxorubicin can potentiate the biological functions of target cells when used at low concentrations, elevating the production and secretion of effector molecules that interfere with the tumor-host relationship.
Journal ArticleDOI
Cytogenetic modifications of friend leukemia cells resistant to adriamycin
TL;DR: When adriamycin-sensitive and resistant Friend leukemia cells were exposed to cytotoxic concentrations, the pulverization phenomenon was not observed and 75-80% of cells were without breaks, suggesting a different mechanism for cytotoxicity in sensitive and resistant cells.