Joseph M. Dennis

TL;DR: A commercially available dialkyl triarylmonophosphine-supported palladium catalyst is utilized that facilitates a broad range of C-N coupling reactions in the presence of weak, soluble bases and shows extraordinary tolerance for even highly base-sensitive functional groups.

TL;DR: This work designed a new air-stable and easily prepared Ni(II) precatalyst bearing an electron-deficient bidentate phosphine ligand that enables the cross-coupling of aryl triflates with aries using triethylamine (TEA) as base and determined that precluding Lewis acid-base complexation between the Ni catalyst and the base, due to steric factors, is important for avoiding catalyst inhibition.

TL;DR: A model in which the turnover-limiting step of the catalytic cycle depends on the relative nucleophilicity of the base compared to that of the amine is proposed, which guided the discovery of new reaction conditions for the coupling of weakly binding amines, including secondary aryl amines which were unreactive nucleophiles in the original protocol.

TL;DR: In this paper, Pd-catalyzed carbon-nitrogen cross-coupling has enabled the use of soluble organic bases instead of insoluble or strong inorganic bases that are traditionally employed.

TL;DR: A rhodium-catalyzed cross-coupling of aryl and aliphatic quinolinyl ketones with boronic acids has been developed, providing good to excellent yields of the new ketones, particularly those containing electron-withdrawing substituents.