A
Akio Kobayashi
Researcher at University of Washington
Publications - 39
Citations - 7632
Akio Kobayashi is an academic researcher from University of Washington. The author has contributed to research in topics: Population & Nephron. The author has an hindex of 27, co-authored 34 publications receiving 6735 citations. Previous affiliations of Akio Kobayashi include Baylor College of Medicine & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
Benjamin D. Humphreys,Benjamin D. Humphreys,Shuei-Liong Lin,Shuei-Liong Lin,Akio Kobayashi,Thomas E. Hudson,Brian T. Nowlin,Joseph V. Bonventre,Joseph V. Bonventre,M. Todd Valerius,Andrew P. McMahon,Jeremy S. Duffield,Jeremy S. Duffield +12 more
TL;DR: Data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease.
Journal ArticleDOI
Six2 Defines and Regulates a Multipotent Self-Renewing Nephron Progenitor Population throughout Mammalian Kidney Development
Akio Kobayashi,M. Todd Valerius,Joshua W. Mugford,Thomas L. Carroll,Michelle Self,Guillermo Oliver,Andrew P. McMahon +6 more
TL;DR: Clonal analysis indicates that at least some Six2-expressing cells are multipotent, contributing to multiple domains of the nephron, and observations suggest that Six2 activity cell-autonomously regulates a multipotent nephrons progenitor population.
Journal ArticleDOI
Intrinsic Epithelial Cells Repair the Kidney after Injury
Benjamin D. Humphreys,Benjamin D. Humphreys,M. Todd Valerius,Akio Kobayashi,Joshua W. Mugford,Savuth Soeung,Jeremy S. Duffield,Andrew P. McMahon,Joseph V. Bonventre,Joseph V. Bonventre,Joseph V. Bonventre +10 more
TL;DR: Results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney.
Journal ArticleDOI
Functional analysis of Sox8 and Sox9 during sex determination in the mouse.
Marie-Christine Chaboissier,Akio Kobayashi,Akio Kobayashi,Valerie I.P. Vidal,Susanne Lützkendorf,Henk J. G. van de Kant,Michael Wegner,Dirk G. de Rooij,Richard R. Behringer,Andreas Schedl +9 more
TL;DR: The studies presented here are the first experimental proof for an essential role for Sox9 in mediating a switch from the ovarian pathway to the testicular pathway and double knock-out analyses suggest that Sox8 reinforces Sox9 function in testis differentiation of mice.
Journal ArticleDOI
Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
Yuna Kim,Akio Kobayashi,Ryohei Sekido,Leo DiNapoli,Jennifer Brennan,Marie-Christine Chaboissier,Francis Poulat,Richard R. Behringer,Robin Lovell-Badge,Blanche Capel +9 more
TL;DR: It is shown through gain- and loss-of-function experiments that fibroblast growth factor 9 (FGF9) and WNT4 act as opposing signals to regulate sex determination, and the fate of the gonad is controlled by antagonism between Fgf9 and Wnt4.