Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury
Won K. Han,Won K. Han,Veronique Bailly,Veronique Bailly,Rekha Abichandani,Rekha Abichandani,Ravi Thadhani,Ravi Thadhani,Joseph V. Bonventre,Joseph V. Bonventre +9 more
TLDR
A soluble form of human KIM-1 can be detected in the urine of patients with ATN and may serve as a useful biomarker for renal proximal tubule injury facilitating the early diagnosis of the disease and serving as a diagnostic discriminator.About:
This article is published in Kidney International.The article was published on 2002-07-01 and is currently open access. It has received 1597 citations till now. The article focuses on the topics: Acute tubular necrosis & Kidney.read more
Citations
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KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
Journal ArticleDOI
Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
Jaya Mishra,Catherine L. Dent,Ridwan Tarabishi,Mark Mitsnefes,Qing Ma,Caitlin Kelly,Stacey M Ruff,Kamyar Zahedi,Mingyuan Shao,Judy A. Bean,Kiyoshi Mori,Jonathan Barasch,Prasad Devarajan +12 more
TL;DR: Univariate analysis showed a significant correlation between acute renal injury and the following: urine and serum concentrations of NGAL at 2 h, and cardiopulmonary bypass time.
Journal ArticleDOI
Acute kidney injury
TL;DR: Evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease, and new diagnostic techniques (eg, renal biomarkers) might help with early diagnosis.
Journal ArticleDOI
Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury
Jaya Mishra,Qing Ma,Anne E. Prada,Mark Mitsnefes,Kamyar Zahedi,Jun Yang,Jonathan Barasch,Prasad Devarajan +7 more
TL;DR: The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury.
Journal ArticleDOI
Cellular pathophysiology of ischemic acute kidney injury
Joseph V. Bonventre,Li Yang +1 more
TL;DR: The major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease are reviewed.
References
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Hospital-acquired renal insufficiency: A prospective study
TL;DR: It is concluded that there is a substantial risk of the development of renal failure in hospital and that the mortality rate due to hospital-acquired renal insufficiency remains high.
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Kidney Injury Molecule-1 (KIM-1), a Putative Epithelial Cell Adhesion Molecule Containing a Novel Immunoglobulin Domain, Is Up-regulated in Renal Cells after Injury
Takaharu Ichimura,Joseph V. Bonventre,Veronique Bailly,Wei Henry,Catherine Hession,Richard L. Cate,Michele Sanicola +6 more
TL;DR: Structurally and expression data suggest that KIM-1 is an epithelial cell adhesion molecule up-regulated in the cells, which are dedifferentiated and undergoing replication, and may play an important role in the restoration of the morphological integrity and function to postischemic kidney.
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Treatment of acute renal failure
TL;DR: The purpose of this perspective is to understand the results of the recent, largely negative, clinical trials in view of recent advances in the epidemiology of ARF.
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Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.
TL;DR: The temporal and nephron segment expressions of various proteins implicated in mitogenesis, differentiation, and injury support the view that the mature renal S3 segment epithelial cell can be a progenitor cell.
Journal ArticleDOI
Acute renal failure in the patient undergoing cardiac operation : prevalence, mortality rate, and main risk factors
G. Zanardo,P. Michielon,Agostino Paccagnella,Paolo Rosi,Mauro Caló,Valeria Salandin,Antonia Da Ros,Federica Michieletto,Giuseppe Simini +8 more
TL;DR: It is concluded that in patients undergoing cardiac operation without preexisting renal dysfunction the likelihood of severe renal complications is reasonably low, but the associated mortality remains high, and a prominent role in the development of postoperative acute renal failure must be recognized.