J
Joseph Yang
Researcher at University of California, San Francisco
Publications - 50
Citations - 4933
Joseph Yang is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Transplantation & Stem cell. The author has an hindex of 29, co-authored 48 publications receiving 4641 citations. Previous affiliations of Joseph Yang include San Francisco VA Medical Center & University of Michigan.
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Journal ArticleDOI
Cell sheet engineering: recreating tissues without biodegradable scaffolds.
Joseph Yang,Masayuki Yamato,Chinatsu Kohno,Ayako Nishimoto,Hidekazu Sekine,Fumio Fukai,Teruo Okano +6 more
TL;DR: Cell sheet engineering allows for tissue regeneration by either direct transplantation of cell sheets to host tissues or the creation of three-dimensional structures via the layering of individual cell sheets.
Journal ArticleDOI
Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets
Kazuo Ohashi,Takashi Yokoyama,Masayuki Yamato,Hiroyuki Kuge,Hiromichi Kanehiro,Masahiro Tsutsumi,Toshihiro Amanuma,Hiroo Iwata,Joseph Yang,Teruo Okano,Yoshiyuki Nakajima +10 more
TL;DR: A method to engineer a uniformly continuous sheet of hepatic tissue using isolated primary hepatocytes cultured on temperature-responsive surfaces is developed, which resulted in efficient engraftment to the surrounding cells, with the formation of two-dimensional hepatic tissues that stably persisted for longer than 200 d.
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Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues.
Tatsuya Shimizu,Hidekazu Sekine,Joseph Yang,Yuki Isoi,Masayuki Yamato,Akihiko Kikuchi,Eiji Kobayashi,Teruo Okano +7 more
TL;DR: C cultured cell sheet integration methods overcome long‐standing barriers to producing thick, vascularized tissues, revealing a possible solution for the clinical repair of various damaged organs, including the impaired myocardium.
Journal ArticleDOI
Reconstruction of functional tissues with cell sheet engineering.
Joseph Yang,Masayuki Yamato,Tatsuya Shimizu,Hidekazu Sekine,Kazuo Ohashi,Masato Kanzaki,Takeshi Ohki,Kohji Nishida,Teruo Okano +8 more
TL;DR: Cell sheet engineering provides a novel alternative for regenerative medicine approaches that require the re-creation of functional tissue structures by exploiting the unique ability of cell sheets to generate three-dimensional tissues composed of only cultured cells and their deposited extracellular matrix.
Journal ArticleDOI
Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts.
Hidekazu Sekine,Tatsuya Shimizu,Kyoko Hobo,Sachiko Sekiya,Joseph Yang,Masayuki Yamato,Hiromi Kurosawa,Eiji Kobayashi,Teruo Okano +8 more
TL;DR: In vitro engineering of 3-dimensional cardiac tissues with preformed EC networks that can be easily connected to host vessels can contribute to the reconstruction of myocardial tissue grafts with a high potential for cardiac function repair.