H
Hidekazu Sekine
Publications - 64
Citations - 4609
Hidekazu Sekine is an academic researcher. The author has contributed to research in topics: Transplantation & Tissue engineering. The author has an hindex of 22, co-authored 55 publications receiving 4142 citations.
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Cell sheet engineering: recreating tissues without biodegradable scaffolds.
Joseph Yang,Masayuki Yamato,Chinatsu Kohno,Ayako Nishimoto,Hidekazu Sekine,Fumio Fukai,Teruo Okano +6 more
TL;DR: Cell sheet engineering allows for tissue regeneration by either direct transplantation of cell sheets to host tissues or the creation of three-dimensional structures via the layering of individual cell sheets.
Journal ArticleDOI
Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues.
Tatsuya Shimizu,Hidekazu Sekine,Joseph Yang,Yuki Isoi,Masayuki Yamato,Akihiko Kikuchi,Eiji Kobayashi,Teruo Okano +7 more
TL;DR: C cultured cell sheet integration methods overcome long‐standing barriers to producing thick, vascularized tissues, revealing a possible solution for the clinical repair of various damaged organs, including the impaired myocardium.
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Reconstruction of functional tissues with cell sheet engineering.
Joseph Yang,Masayuki Yamato,Tatsuya Shimizu,Hidekazu Sekine,Kazuo Ohashi,Masato Kanzaki,Takeshi Ohki,Kohji Nishida,Teruo Okano +8 more
TL;DR: Cell sheet engineering provides a novel alternative for regenerative medicine approaches that require the re-creation of functional tissue structures by exploiting the unique ability of cell sheets to generate three-dimensional tissues composed of only cultured cells and their deposited extracellular matrix.
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In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels
Hidekazu Sekine,Tatsuya Shimizu,Katsuhisa Sakaguchi,Izumi Dobashi,Masanori Wada,Masayuki Yamato,Eiji Kobayashi,Mitsuo Umezu,Teruo Okano +8 more
TL;DR: The production of functional cardiac tissue sheets with perfusable blood vessels is reported, which increase the thickness and survival of transplanted tissue.
Journal ArticleDOI
Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts.
Hidekazu Sekine,Tatsuya Shimizu,Kyoko Hobo,Sachiko Sekiya,Joseph Yang,Masayuki Yamato,Hiromi Kurosawa,Eiji Kobayashi,Teruo Okano +8 more
TL;DR: In vitro engineering of 3-dimensional cardiac tissues with preformed EC networks that can be easily connected to host vessels can contribute to the reconstruction of myocardial tissue grafts with a high potential for cardiac function repair.