J
Josiah B. Passmore
Researcher at University of Exeter
Publications - 12
Citations - 283
Josiah B. Passmore is an academic researcher from University of Exeter. The author has contributed to research in topics: Peroxisome & Endoplasmic reticulum. The author has an hindex of 6, co-authored 10 publications receiving 155 citations. Previous affiliations of Josiah B. Passmore include Utrecht University.
Papers
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Journal ArticleDOI
Co-regulation map of the human proteome enables identification of protein functions
Georg Kustatscher,Piotr Grabowski,Tina A. Schrader,Josiah B. Passmore,Michael Schrader,Juri Rappsilber,Juri Rappsilber +6 more
TL;DR: The machine learning algorithm treeClust was applied to reveal functional associations between co-regulated human proteins from ProteomeHD, a compilation of its own data and datasets from the Proteomics Identifications database, which produced a co-regulation map of the human proteome.
Journal ArticleDOI
A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes
Inês G. Castro,David M. Richards,Jeremy Metz,Joseph L. Costello,Josiah B. Passmore,Tina A. Schrader,Ana Gouveia,Daniela Ribeiro,Michael Schrader +8 more
TL;DR: A role for Mitochondrial Rho GTPase 1 (MIRO1) is identified as an adaptor for microtubule‐dependent peroxisome motility in mammalian cells and it is demonstrated that MIRO1‐mediated pulling forces contribute to perox isome membrane elongation and proliferation in cellular models of peroxISome disease.
Book ChapterDOI
Multi-localized Proteins: The Peroxisome-Mitochondria Connection
TL;DR: What emerges is that sharing of proteins between these two organelles plays a key role in their cooperative functions which, based on new findings, may be more extensive than originally envisaged.
Journal ArticleDOI
The respiratory chain inhibitor rotenone affects peroxisomal dynamics via its microtubule-destabilising activity.
Josiah B. Passmore,Sónia Pinho,Maria Gomez-Lazaro,Maria Gomez-Lazaro,Michael Schrader,Michael Schrader +5 more
TL;DR: It is shown that rotenone treatment of COS-7 cells alters peroxisome morphology and distribution, but this effect is related to its microtubule-destabilising activity rather than to the generation of oxidative stress.
Journal ArticleDOI
Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation
Josiah B. Passmore,Ruth E. Carmichael,Tina A. Schrader,Luis F. Godinho,Sacha Ferdinandusse,Celien Lismont,Yunhong Wang,Christian Hacker,Markus Islinger,Marc Fransen,David M. Richards,Peter Freisinger,Michael Schrader +12 more
TL;DR: It is shown that MFF deficiency does not cause alterations to overall peroxisomal biochemical function, however, loss of MFF results in reduced import-competency of the peroxISomal compartment and leads to the accumulation of pre-peroxisome membrane structures in MFF-deficient cells.