J
Jozef Goris
Researcher at Katholieke Universiteit Leuven
Publications - 134
Citations - 9528
Jozef Goris is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Phosphatase & Protein phosphatase 2. The author has an hindex of 50, co-authored 134 publications receiving 9193 citations.
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Journal ArticleDOI
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.
Veerle Janssens,Jozef Goris +1 more
TL;DR: The regulatory ability of PTPA (PTPase activator), originally identified as a protein stimulating the phosphotyrosine phosphatase activity of PP2A, will be discussed, alongside the other regulatory inputs.
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Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.
Gerard Drewes,Birgit Lichtenberg-Kraag,Frank Döring,Eva Maria Mandelkow,Jacek Biernat,Jozef Goris,M Dorée,E. Mandelkow +7 more
TL;DR: It is proposed that MAP kinase is abnormally active in Alzheimer brain tissue, or that the corresponding phosphatases are abnormally passive, due to a breakdown of the normal regulatory mechanisms.
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PP2A: the expected tumor suppressor
TL;DR: In this article, the authors showed that PR61/B′γ, a specific third regulatory subunit of PP2A, can substitute for the viral SV40 protein small t antigen in causing tumorigenic transformation of several human cell lines.
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PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).
TL;DR: The effects of specific post-translational modifications of the C-terminal tail of the catalytic subunit indicate that a 'code' might regulate dynamic exchange of regulatory B-type subunits, thus affecting the specificity of PP2A.
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Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells
Michael H.A. Schmitz,Michael H.A. Schmitz,Michael H.A. Schmitz,Michael Held,Michael Held,Veerle Janssens,James R. A. Hutchins,Otto Hudecz,Elitsa Ivanova,Jozef Goris,Laura Trinkle-Mulcahy,Angus I. Lamond,Ina Poser,Anthony A. Hyman,Karl Mechtler,Jan-Michael Peters,Daniel W. Gerlich,Daniel W. Gerlich +17 more
TL;DR: A live-cell imaging assay and RNAi knockdown is used to screen a genome-wide library of protein phosphatases for mitotic exit functions in human cells and it is found that PP2A–B55α functions downstream of Cdk1 inactivation.