M
Michael H.A. Schmitz
Researcher at ETH Zurich
Publications - 7
Citations - 2315
Michael H.A. Schmitz is an academic researcher from ETH Zurich. The author has contributed to research in topics: Mitosis & Aurora B kinase. The author has an hindex of 7, co-authored 7 publications receiving 2134 citations. Previous affiliations of Michael H.A. Schmitz include Marine Biological Laboratory & University of Zurich.
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Journal ArticleDOI
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes
Beate Neumann,Thomas Walter,Jean-Karim Hériché,Jutta Bulkescher,Holger Erfle,Christian Conrad,Phill Rogers,Ina Poser,Michael Held,Urban Liebel,Cihan Cetin,Frank Sieckmann,Gregoire Pau,Rolf Kabbe,Annelie Wünsche,Venkata P. Satagopam,Michael H.A. Schmitz,Catherine Chapuis,Daniel W. Gerlich,Reinhard Schneider,Roland Eils,Wolfgang Huber,Jan-Michael Peters,Anthony A. Hyman,Richard Durbin,Rainer Pepperkok,Jan Ellenberg +26 more
TL;DR: This study carried out a genome-wide phenotypic profiling of each of the ∼21,000 human protein-coding genes by two-day live imaging of fluorescently labelled chromosomes, which allowed us to identify hundreds of human genes involved in diverse biological functions including cell division, migration and survival.
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Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization
Patrick Steigemann,Claudia Wurzenberger,Michael H.A. Schmitz,Michael Held,Julien Guizetti,Sandra Maar,Daniel W. Gerlich +6 more
TL;DR: A cell division control mechanism that prevents tetraploidization in human cells with perturbed chromosome segregation is reported and it is proposed that Aurora B is part of a sensor that responds to unsegregated chromatin at the cleavage site.
Journal ArticleDOI
CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging
Michael Held,Michael H.A. Schmitz,Michael H.A. Schmitz,Bernd Fischer,Thomas Walter,Beate Neumann,Michael H. Olma,Matthias Peter,Jan Ellenberg,Daniel W. Gerlich,Daniel W. Gerlich +10 more
TL;DR: A machine-learning method that combines state-of-the-art classification with hidden Markov modeling for annotation of the progression through morphologically distinct biological states is developed, enabling live-cell imaging–based screening with assays that directly score cellular dynamics.
Journal ArticleDOI
Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells
Michael H.A. Schmitz,Michael H.A. Schmitz,Michael H.A. Schmitz,Michael Held,Michael Held,Veerle Janssens,James R. A. Hutchins,Otto Hudecz,Elitsa Ivanova,Jozef Goris,Laura Trinkle-Mulcahy,Angus I. Lamond,Ina Poser,Anthony A. Hyman,Karl Mechtler,Jan-Michael Peters,Daniel W. Gerlich,Daniel W. Gerlich +17 more
TL;DR: A live-cell imaging assay and RNAi knockdown is used to screen a genome-wide library of protein phosphatases for mitotic exit functions in human cells and it is found that PP2A–B55α functions downstream of Cdk1 inactivation.
Journal ArticleDOI
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly
Ying Wai Chan,Luca L. Fava,Andreas Uldschmid,Michael H.A. Schmitz,Daniel W. Gerlich,Erich A. Nigg,Anna Santamaria +6 more
TL;DR: The data reveal hSpindly-mediated dynein functions and highlight a critical role of KT Dynein in spindle orientation, as well as characterizing the function of Spindly in human cells.