J
Ju-Sik Min
Researcher at Korea Research Institute of Bioscience and Biotechnology
Publications - 15
Citations - 805
Ju-Sik Min is an academic researcher from Korea Research Institute of Bioscience and Biotechnology. The author has contributed to research in topics: Mitochondrial fission & Mitochondrion. The author has an hindex of 11, co-authored 15 publications receiving 610 citations. Previous affiliations of Ju-Sik Min include UPRRP College of Natural Sciences & Kyungpook National University.
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Journal ArticleDOI
Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways
Junghyung Park,Ju-Sik Min,Bokyung Kim,Unbin Chae,Jong Won Yun,Myung-Sook Choi,Il-Keun Kong,Kyu-Tae Chang,Dong-Seok Lee +8 more
TL;DR: Results indicate that mitochondria constitute a major source of ROS generation in LPS-mediated activated microglia cells and suggest that a potential strategy in the development of therapy for inflammation-associated degenerative neurological diseases involves targeting the regulation of mitochondrial ROS in microglial cells.
Journal ArticleDOI
Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells.
Junghyung Park,Hoonsung Choi,Hoonsung Choi,Ju-Sik Min,Sun-Ji Park,Sun-Ji Park,Jung-Hak Kim,Jung-Hak Kim,Hyo-Jin Park,Hyo-Jin Park,Bokyung Kim,Jung-Il Chae,Mijung Yim,Dong-Seok Lee,Dong-Seok Lee +14 more
TL;DR: It is demonstrated for the first time that mitochondrial fission regulates mitochondrial ROS production in activated microglial cells and influences the expression of pro‐inflammatory mediators through the activation of NF‐κB and MAPK.
Journal ArticleDOI
Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission
Junghyung Park,Junghyung Park,Ju-Sik Min,Ju-Sik Min,Ju-Sik Min,Unbin Chae,Unbin Chae,Joon Yeop Lee,Kyung-Sik Song,Hyun-Shik Lee,Hyun-Shik Lee,Hong Jun Lee,Sang-Rae Lee,Dong-Seok Lee,Dong-Seok Lee +14 more
TL;DR: Oleuropein suppressed the LPS-induced increase in pro-inflammatory mediators, such as nitric oxide, and pro- inflammatory cytokines, via inhibition of ERK/p38/NF-κB activation and reactive oxygen species (ROS) generation.
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A liver-specific gene expression panel predicts the differentiation status of in vitro hepatocyte models
Dae-Soo Kim,Jea Woon Ryu,Mi Young Son,Jung-Hwa Oh,Kyung-Sook Chung,Sugi Lee,Jeong Ju Lee,Jun Ho Ahn,Ju-Sik Min,Jiwon Ahn,Hyun Mi Kang,Janghwan Kim,Cho Rok Jung,Nam-Soon Kim,Hyun-Soo Cho +14 more
TL;DR: A quantitative and predictive model for differentiated samples, particularly liver‐specific cells or organoids is described and this model can be further expanded to various tissue‐specific organoids; the LiGEP can provide useful information and insights regarding the differentiation status of in vitro liver models.
Journal ArticleDOI
Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability
S. Kim,Yong Beom Lee,Nam-Soon Kim,Yeonsil Hwang,Hwang B,Hwang B,Ju-Sik Min,Ju-Sik Min,Sang Seok Koh +8 more
TL;DR: Recombinant PAUF enhanced proliferation, migration and capillary-like tube formation of human endothelial cells (ECs), consistently with increased neovascularization in vivo, and potentiated the in vitro and in vivo EC angiogenic responses to stromal cell-derived factor-1 (SDF-1), a ligand for CXCR4.