Juan J. Maya

TL;DR: The epidemiology of Klebsiella pneumoniae carbapenemases across continents is summarized, issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control are discussed.

TL;DR: The dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor blaVIM-2 on a class 1 integron and blaKPC- 2 on a Tn4401 transposon, respectively.

TL;DR: La articulacion of the biologia molecular with los sistemas de vigilancia permitio integrar el analisis del fenotipo con los mecanismos de resistencia involucrados en las bacterias estudiadas permitira the elaboracion of guias para el uso adecuado of antimicrobianos y contribuira a the contencion of estas bacterias multirresistentes en Colombia.

TL;DR: Carbapenemases, such as KPC and VIM, are the most powerful β-lactamases, being able to hydrolyze nearly all β- lactams.

TL;DR: Enterobacteriaceae and non fermenting Gram-negative bacilli have become a threat to public health, in part due to their resistance to multiple antibiotic classes, which ultimately have led to an increase in morbidity and mortality.