L
Laura J. Rojas
Researcher at Case Western Reserve University
Publications - 51
Citations - 1165
Laura J. Rojas is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Klebsiella pneumoniae & Medicine. The author has an hindex of 18, co-authored 43 publications receiving 905 citations. Previous affiliations of Laura J. Rojas include Veterans Health Administration & University of Los Andes.
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Journal ArticleDOI
Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?
Steven H. Marshall,Andrea M. Hujer,Andrea M. Hujer,Laura J. Rojas,Laura J. Rojas,Krisztina M. Papp-Wallace,Romney M. Humphries,Brad Spellberg,Kristine M. Hujer,Kristine M. Hujer,Emma K. Marshall,Susan D. Rudin,Susan D. Rudin,Federico Perez,Federico Perez,Brigid Wilson,Ronald B. Wasserman,Linda Chikowski,David L. Paterson,Alejandro J. Vila,David van Duin,Barry N. Kreiswirth,Henry F. Chambers,Vance G. Fowler,Michael R. Jacobs,Mark Pulse,William J. Weiss,Robert A. Bonomo +27 more
TL;DR: In vitro activity of CAZ-AVI in combination with ATM against diverse Enterobacteriaceae possessing MBLs was demonstrated, and the data presented herein require us to carefully consider this new therapeutic combination to treat infections caused by MBL-producing Enterobacteria.
Journal ArticleDOI
Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.
Laura J. Rojas,Laura J. Rojas,Madiha Salim,Eric Cober,Sandra S. Richter,Federico Perez,Federico Perez,Robert A. Salata,Robert C. Kalayjian,Richard R. Watkins,Richard R. Watkins,S H Marshall,Susan D. Rudin,T. Nicholas Domitrovic,Andrea M. Hujer,Kristine M. Hujer,Yohei Doi,Keith S. Kaye,Scott R. Evans,Vance G. Fowler,Robert A. Bonomo,David van Duin +21 more
TL;DR: The apparent polyclonal nature of the isolates suggests de novo emergence of ColR in this cohort as the primary factor driving ColR, and mortality was increased in patients with ColR isolates.
Journal ArticleDOI
A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacteremia in Nine Latin American Countries.
Cesar A. Arias,Cesar A. Arias,Jinnethe Reyes,Lina P Carvajal,Sandra Rincon,Lorena Diaz,Diana Panesso,Diana Panesso,Gabriel Ibarra,Rafael Rios,Jose M. Munita,Mauro José Costa Salles,Carlos Alvarez-Moreno,Jaime Labarca,Coralith Garcia,Carlos M. Luna,Carlos Mejía-Villatoro,Jeannete Zurita,Manuel Guzman-Blanco,Eduardo Rodríguez-Noriega,Apurva Narechania,Laura J. Rojas,Paul J. Planet,Paul J. Planet,Paul J. Planet,George M. Weinstock,Eduardo Gotuzzo,Carlos Seas +27 more
TL;DR: CC5 MRSA was prevalent in bloodstream infections in LA with the exception of Colombia and Ecuador, where USA300-LV is now the dominant lineage.
Journal ArticleDOI
NDM-5 and OXA-181 beta-lactamases: a significant threat continues to spread in the Americas
Laura J. Rojas,Laura J. Rojas,Andrea M. Hujer,Andrea M. Hujer,Susan D. Rudin,Susan D. Rudin,Meredith S. Wright,T. Nicholas Domitrovic,T. Nicholas Domitrovic,Steven H. Marshall,Kristine M. Hujer,Kristine M. Hujer,Sandra S. Richter,Eric Cober,Federico Perez,Federico Perez,Mark Raymond Adams,David van Duin,Robert A. Bonomo +18 more
TL;DR: The CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant Klebsiella pneumoniae ST147 isolate harboring blaNDM-5 and blaOXA-181 from a young man who underwent abdominal surgery in India.
Journal ArticleDOI
Dissemination of High-Risk Clones of Extensively Drug-Resistant Pseudomonas aeruginosa in Colombia
Adriana Correa,Rosa del Campo,Marcela Perenguez,Victor M. Blanco,Mercedes Rodríguez-Baños,Federico Perez,Federico Perez,Juan J. Maya,Laura J. Rojas,Rafael Cantón,Cesar A. Arias,Cesar A. Arias,Maria V. Villegas +12 more
TL;DR: The dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor blaVIM-2 on a class 1 integron and blaKPC- 2 on a Tn4401 transposon, respectively.