Juan Lucas Argueso

TL;DR: In this article, the authors reported the molecular genetic analysis of a PE-2 derived diploid (JAY270) and the complete genome sequence of a haploid derivative (Jay291), which is highly heterozygous (approximately 2 SNPs/kb) and has several structural polymorphisms between homologous chromosomes.

TL;DR: It is concluded that only those DSBs that fall at the 3–5% of the genome composed of repetitive DNA elements are efficient at generating rearrangements with dispersed small repeats across the genome, whereas D SBs in unique sequences are confined to recombinational repair between the large regions of homology contained in sister chromatids or homologous chromosomes.

TL;DR: It is suggested that meiotic crossing over can occur in yeast through three distinct crossover pathways: in one pathway, MUS81-MMS4 promotes interference-independent crossing over; in a second pathway, both MSH 4-MSH5 and MLH1-MLH3 promote interference-dependent crossovers; and in a third pathway, which appears to be repressed by MSH4- MSH5, yields deleterious crossover.

TL;DR: Roles for MMR proteins in repairing mismatches that occur during recombination, particularly during meiosis are discussed and how studying this process has helped to refine models of double-strand break repair is explored, and particularly to the understanding of gene conversion gradients.

TL;DR: The results indicate that the diploid yeast nuclear genome is remarkably stable during the vegetative and meiotic cell cycles and support the hypothesis that peripheral regions of chromosomes are more dynamic than gene-rich central sections where structural rearrangements could be deleterious.