J
Juan Pedro Kusanovic
Researcher at National Institutes of Health
Publications - 251
Citations - 19185
Juan Pedro Kusanovic is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Pregnancy & Amniotic fluid. The author has an hindex of 65, co-authored 246 publications receiving 17350 citations. Previous affiliations of Juan Pedro Kusanovic include Detroit Medical Center & Wayne State University.
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Journal ArticleDOI
The preterm parturition syndrome
Roberto Romero,Jimmy Espinoza,Juan Pedro Kusanovic,Francesca Gotsch,Sonia S. Hassan,Offer Erez,Tinnakorn Chaiworapongsa,Moshe Mazor +7 more
TL;DR: The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin‐releasing factor related).
Journal ArticleDOI
A novel signaling pathway impact analysis
Adi L. Tarca,Sorin Draghici,Purvesh Khatri,Sonia S. Hassan,Pooja Mittal,Jung-Sun Kim,Chong Jai Kim,Juan Pedro Kusanovic,Roberto Romero +8 more
TL;DR: A novel signaling pathway impact analysis (SPIA) that combines the evidence obtained from the classical enrichment analysis with a novel type of evidence, which measures the actual perturbation on a given pathway under a given condition.
Journal ArticleDOI
The role of inflammation and infection in preterm birth.
Roberto Romero,Jimmy Espinoza,Jimmy Espinoza,Luís F. Gonçalves,Luís F. Gonçalves,Juan Pedro Kusanovic,Lara A. Friel,Sonia S. Hassan,Sonia S. Hassan +8 more
TL;DR: The role of inflammation in preterm and term parturition is reviewed, which is the only pathological process for which both a firm causal link with preterm birth and a molecular pathophysiology defined are established.
Journal ArticleDOI
Microbial Prevalence, Diversity and Abundance in Amniotic Fluid During Preterm Labor: A Molecular and Culture-Based Investigation
Daniel B. DiGiulio,Daniel B. DiGiulio,Roberto Romero,Roberto Romero,Harold P. Amogan,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Elisabeth M. Bik,Elisabeth M. Bik,Francesca Gotsch,Chong Jai Kim,Chong Jai Kim,Offer Erez,Offer Erez,Sam Edwin,David A. Relman,David A. Relman +16 more
TL;DR: The amniotic cavity of women in preterm labor harbors DNA from a greater diversity of microbes than previously suspected, including as-yet uncultivated, previously-uncharacterized taxa.
Journal ArticleDOI
Inflammation in preterm and term labour and delivery.
Roberto Romero,Jimmy Espinoza,Jimmy Espinoza,Luís F. Gonçalves,Luís F. Gonçalves,Juan Pedro Kusanovic,Lara A. Friel,Jyh Kae Nien +7 more
TL;DR: It is possible that modulation of inflammation using anti-inflammatory cytokines, corticoids, antioxidants and/or other factors may complement antibiotic therapy and limit fetal injury.